Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)
about
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinaseStructural and functional properties of platelet-derived growth factor and stem cell factor receptorsOncogenic Signaling Adaptor ProteinsCrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signalingInterleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cellsInterplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transductionSHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKLPhosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein.CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.Involvement of the adapter protein CRKL in integrin-mediated adhesion.Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia.Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glandsBeyond the RING: CBL proteins as multivalent adapters.Classification and subtype prediction of adult soft tissue sarcoma by functional genomics.Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix.Signaling of c-kit in dendritic cells influences adaptive immunity.Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: regulators of T cell differentiationEscherichia coli virulence protein NleH1 interaction with the v-Crk sarcoma virus CT10 oncogene-like protein (CRKL) governs NleH1 inhibition of the ribosomal protein S3 (RPS3)/nuclear factor κB (NF-κB) pathway.Cooperate concept of metastasis: site-specific requirement of activated differentiation and dynamic deterioration.SOCS6 is a selective suppressor of receptor tyrosine kinase signaling.Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation.CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion.Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.Evaluation of normal and neoplastic human mast cells for expression of CD172a (SIRPalpha), CD47, and SHP-1.c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit.Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor.The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells.Crk-like adapter protein is overexpressed in cervical carcinoma, facilitates proliferation, invasion and chemoresistance, and regulates Src and Akt signaling.Opposing roles of KIT and ABL1 in the therapeutic response of gastrointestinal stromal tumor (GIST) cells to imatinib mesylate.SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation.
P2860
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P2860
Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@ast
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@en
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@nl
type
label
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@ast
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@en
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@nl
prefLabel
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@ast
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@en
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@nl
P2093
P2860
P3181
P356
P1476
Steel factor induces tyrosine ...... ositol 3-kinase, and p120(CBL)
@en
P2093
G Shrikhande
J D Griffin
K V Prasad
P2860
P304
P3181
P356
10.1074/JBC.272.15.10248
P407
P577
1997-04-11T00:00:00Z