Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase - Test2 - elhamkhani - TriplyDB

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

http://www.wikidata.org/entity/Q28345101

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Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1 Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase Human APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1 Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress.Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA.The current state of eukaryotic DNA base damage and repair Mismatch Repair in Methylated DNA: STRUCTURE AND ACTIVITY OF THE MISMATCH-SPECIFIC THYMINE GLYCOSYLASE DOMAIN OF METHYL-CpG-BINDING PROTEIN MBD4 The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.Mimicking damaged DNA with a small molecule inhibitor of human UNG2.Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase.Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.An interplay of the base excision repair and mismatch repair pathways in active DNA demethylation.Uracil in DNA and its processing by different DNA glycosylases Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs.Phylogenomic analysis of the uracil-DNA glycosylase superfamily Class-switch recombination: after the dawn of AID.Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.UNG shapes the specificity of AID-induced somatic hypermutation.Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination Monitoring eukaryotic and bacterial UDG repair activity with DNA-multifluorophore sensors Origin of endogenous DNA abasic sites in Saccharomyces cerevisiae 5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase Steady-state, pre-steady-state, and single-turnover kinetic measurement for DNA glycosylase activity.DNA base repair--recognition and initiation of catalysis.

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Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

http://www.wikidata.org/entity/Q28345101

description

2001 nî lūn-bûn

@nan

2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի օգոստոսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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The EMBO Journal

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Excision of deaminated cytosin ...... e SMUG1 uracil-DNA glycosylase

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D E Barnes

http://www.w3.org/2001/XMLSchema#string

G L Verdine

http://www.w3.org/2001/XMLSchema#string

K A Haushalter

http://www.w3.org/2001/XMLSchema#string

P Robins

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Instability and decay of the primary structure of DNA

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

Post-replicative base excision repair in replication foci

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells

The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair.

Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair

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scholarly article

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1619610

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10.1093/EMBOJ/20.15.4278

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15

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20

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11858675

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11483530

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149160

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