Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
about
Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseaseActive DNA demethylation in post-mitotic neurons: a reason for optimismMechanism and function of oxidative reversal of DNA and RNA methylationBiochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNADNA methylation, its mediators and genome integrityBase excision repairRegulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient miceUracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationSMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stressSingle-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.AID enzymatic activity is inversely proportional to the size of cytosine C5 orbital cloud.The theory of RNA-mediated gene evolutionAn interplay of the base excision repair and mismatch repair pathways in active DNA demethylation.Gadd45b and N-methyl-D-aspartate induced DNA demethylation in postmitotic neurons.Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNAEstablishing a model for assessing DNA damage in murine brain cells as a molecular marker of chemotherapy-associated cognitive impairment.Reversing DNA methylation: mechanisms, genomics, and biological functions.Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.Alternative roles for oxidized mCs and TETs.Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.Association of a novel point mutation in MSH2 gene with familial multiple primary cancers.TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation.Genetic variations in base excision repair pathway and risk of bladder cancer: a case-control study in the United States.Identification of a prototypical single-stranded uracil DNA glycosylase from Listeria innocua.Novel MSH2 splice-site mutation in a young patient with Lynch syndrome.DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity
P2860
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P2860
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@ast
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@en
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@nl
type
label
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@ast
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@en
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@nl
prefLabel
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@ast
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@en
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@nl
P2093
P2860
P356
P1476
Germline ablation of SMUG1 DNA ...... osition of Ung-/-Msh2-/- mice.
@en
P2093
Cristina Rada
Felix A Dingler
Kristin Kemmerich
Michael S Neuberger
P2860
P304
P356
10.1093/NAR/GKS259
P407
P577
2012-03-24T00:00:00Z