Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors
about
Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sitesStandard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonistsPharmacology of nociceptin and its receptor: a novel therapeutic targetHighly selective agonists for substance P receptor subtypesDelta-opioid mediated inhibitions of acute and prolonged noxious-evoked responses in rat dorsal horn neuronesActivity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR geneNociceptin produces antinociception after spinal administration in amphibiansThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsXendorphin B1, a novel opioid-like peptide determined from a Xenopus laevis brain cDNA library, produces opioid antinociception after spinal administration in amphibiansDevelopment of neuropeptide drugs that cross the blood-brain barrier."DAKLI": a multipurpose ligand with high affinity and selectivity for dynorphin (kappa opioid) binding sitesA three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands.Delta-opiate DPDPE in magnetically oriented phospholipid micelles: binding and arrangement of aromatic pharmacophores.The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.Complementarity of delta opioid ligand pharmacophore and receptor models.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillaminesOpioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints.Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.N-methylated cyclic enkephalin analogues retain high opioid receptor binding affinity.Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).New reagents, reactions, and peptidomimetics for drug design.Organic chemistry and biology: chemical biology through the eyes of collaboration.Lipid bilayers on polyacrylamide brushes for inclusion of membrane proteinsNeuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography.Evidence for lack of modulation of mu-opioid agonist action by delta-opioid agonists in the mouse vas deferens and guinea-pig ileum.Dissociation of the opioid receptor mechanisms that control mechanical and heat painPresynaptic opioid receptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortexNew paradigms and tools in drug design for pain and addictionGlycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus[Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon.Delta-opioid receptors mediate inhibition of fast excitatory postsynaptic potentials in cat parasympathetic colonic ganglia.Evaluation of opioid-induced antinociceptive effects in anaesthetized and conscious animals.Effects of naloxone and opioid agonists on gastric excitatory responses to stimulation of the vagus nerve in catsDifferential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: correlation with receptor distributionNociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphinsModulation of peristalsis in the guinea-pig isolated small intestine by exogenous and endogenous opioids.Opioid activity of dermenkephalin analogues in the guinea-pig myenteric plexus and the hamster vas deferens.
P2860
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P2860
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors
description
1983 nî lūn-bûn
@nan
1983 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1983 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1983年の論文
@ja
1983年論文
@yue
1983年論文
@zh-hant
1983年論文
@zh-hk
1983年論文
@zh-mo
1983年論文
@zh-tw
1983年论文
@wuu
name
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@ast
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@en
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@nl
type
label
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@ast
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@en
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@nl
prefLabel
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@ast
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@en
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@nl
P2093
P2860
P356
P1476
Bis-penicillamine enkephalins ...... toward delta opioid receptors
@en
P2093
H I Mosberg
H I Yamamura
J J Galligan
P2860
P304
P356
10.1073/PNAS.80.19.5871
P407
P577
1983-10-01T00:00:00Z