Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways - Test2 - elhamkhani - TriplyDB

Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways

Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways

http://www.wikidata.org/entity/Q28473763

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Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets?Analysis of the small RNA transcriptional response in multidrug-resistant Staphylococcus aureus after antimicrobial exposure Fluorescence-Based Strategies to Investigate the Structure and Dynamics of Aptamer-Ligand Complexes Linking aptamer-ligand binding and expression platform folding in riboswitches: prospects for mechanistic modeling and design Molecular recognition and function of riboswitches A decade of riboswitches Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch A Disconnect between High-Affinity Binding and Efficient Regulation by Antifolates and Purines in the Tetrahydrofolate Riboswitch Selective small-molecule inhibition of an RNA structural element Emerging applications of riboswitches - from antibacterial targets to molecular tools Metabolite recognition principles and molecular mechanisms underlying riboswitch function Structure and function of preQ1 riboswitches Prospects for riboswitch discovery and analysis Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs Phylogenetic analysis and comparative genomics of purine riboswitch distribution in prokaryotes Mining Functional Elements in Messenger RNAs: Overview, Challenges, and Perspectives Cartography of methicillin-resistant S. aureus transcripts: detection, orientation and temporal expression during growth phase and stress conditions Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation The Staphylococcus aureus RNome and its commitment to virulence.The purine riboswitch as a model system for exploring RNA biology and chemistry The expanding view of RNA and DNA function.Identification of ligand analogues that control c-di-GMP riboswitches.Novel insights of structure-based modeling for RNA-targeted drug discovery.The yjdF riboswitch candidate regulates gene expression by binding diverse azaaromatic compounds.Constitutive regulatory activity of an evolutionarily excluded riboswitch variant.A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors.Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria.Biophysical Approaches to Bacterial Gene Regulation by Riboswitches.Characterization of a vraG Mutant in a Genetically Stable Staphylococcus aureus Small-Colony Variant and Preliminary Assessment for Use as a Live-Attenuated Vaccine against Intrammamary Infections.Small molecule fluoride toxicity agonists.Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes.De Novo Guanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus Infection In Vivo RNA-mediated regulation in pathogenic bacteria.Structure and mechanism of purine-binding riboswitches.How to cope with the quest for new antibiotics.Riboswitch structure in the ligand-free state.Current knowledge on regulatory RNAs and their machineries in Staphylococcus aureus.Structural insights into the interactions of xpt riboswitch with novel guanine analogues: a molecular dynamics simulation study.

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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways

http://www.wikidata.org/entity/Q28473763

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Novel riboswitch ligand analog ...... ine-related metabolic pathways

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JOURNAL.PPAT.1000865

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Novel riboswitch ligand analog ...... ine-related metabolic pathways

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Daniel A Lafontaine

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Eric Brouillette

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Jérôme Mulhbacher

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Marianne Allard

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P2860

Ligand recognition determinants of guanine riboswitches

Essential Bacillus subtilis genes

Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria

Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine

Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs

Nucleotide biosynthesis is critical for growth of bacteria in human blood.

Differential effect of rpoB mutations on antibacterial activities of rifampicin and KRM-1648 against Staphylococcus aureus.

Phylogeny in aid of the present and novel microbial lineages: diversity in Bacillus.

Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA.

Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability.

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e1000865

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scholarly article

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10.1371/JOURNAL.PPAT.1000865

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4

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Francois Malouin

Louis-Charles Fortier

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2010-04-22T00:00:00Z

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43346140

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20421948

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2858708

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