In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms
about
Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levelsSolvent microenvironments and copper binding alters the conformation and toxicity of a prion fragmentHeat shock proteins: cellular and molecular mechanisms in the central nervous system.Pulling rabbits to reveal the secrets of the prion proteinA Drosophila model of GSS syndrome suggests defects in active zones are responsible for pathogenesis of GSS syndrome.Prion protein facilitates synaptic vesicle release by enhancing release probability.Sequence-dependent prion protein misfolding and neurotoxicity.Changes in HSP gene and protein expression in natural scrapie with brain damagePrion protein in Caenorhabditis elegans: Distinct models of anti-BAX and neuropathology.Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.Drosophila models of proteinopathies: the little fly that could.Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's diseaseOverexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interactionPurification of transcripts and metabolites from Drosophila headsPolar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in DrosophilaDrosophila enhancer-Gal4 lines show ectopic expression during development.Role of proteomics in understanding prion infection.The chaperone Grp78 in protein folding disorders of the nervous system.Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity.Exploring prion protein biology in flies: genetics and beyond.secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloidsA single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila.Molecular dynamics studies on the NMR structures of rabbit prion protein wild type and mutants: surface electrostatic charge distributions.Plasminogen: A cellular protein cofactor for PrPSc propagation.Launching Hsp70 neuroprotection: two drugs better than oneShort Aβ peptides attenuate Aβ42 toxicity in vivo.Risk profile related to production and consumption of insects as food and feedFunctional amyloids: interrelationship with other amyloids and therapeutic assessment to treat neurodegenerative diseases.Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival.Membrane heat shock protein 70: a theranostic target for cancer therapy.Sphingolipids regulate neuromuscular synapse structure and function in Drosophila
P2860
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P2860
In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
In vivo generation of neurotox ...... mulation of misfolded isoforms
@ast
In vivo generation of neurotox ...... mulation of misfolded isoforms
@en
In vivo generation of neurotox ...... mulation of misfolded isoforms
@nl
type
label
In vivo generation of neurotox ...... mulation of misfolded isoforms
@ast
In vivo generation of neurotox ...... mulation of misfolded isoforms
@en
In vivo generation of neurotox ...... mulation of misfolded isoforms
@nl
prefLabel
In vivo generation of neurotox ...... mulation of misfolded isoforms
@ast
In vivo generation of neurotox ...... mulation of misfolded isoforms
@en
In vivo generation of neurotox ...... mulation of misfolded isoforms
@nl
P2093
P2860
P1433
P1476
In vivo generation of neurotox ...... mulation of misfolded isoforms
@en
P2093
Ana C Cepeda-Nieto
Claudio Soto
Diego E Rincon-Limas
Joaquín Castilla
Marco A Morales-Garza
Melisa Gómez-Velazquez
Pedro Fernandez-Funez
Sergio Casas-Tinto
P2860
P304
P356
10.1371/JOURNAL.PGEN.1000507
P407
P577
2009-06-01T00:00:00Z