Allosteric interactions between the myristate- and ATP-site of the Abl kinase
about
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognitionHydrogen exchange mass spectrometry: are we out of the quicksand?ACK1 tyrosine kinase: targeted inhibition to block cancer cell proliferationMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionDefying c-Abl signaling circuits through small allosteric compounds.Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-capPartial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitorsComputational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesAllosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315IParallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling.Dynamics of protein kinases: insights from nuclear magnetic resonance.Structure and dynamic regulation of Abl kinases.H/D exchange centroid monitoring is insufficient to show differences in the behavior of protein states.SPLINTS: small-molecule protein ligand interface stabilizers.Innovation in academic chemical screening: filling the gaps in chemical biologyDevelopment of an effective therapy for chronic myelogenous leukemiaOxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases?Combination therapy with nilotinib for drug-sensitive and drug-resistant BCR-ABL-positive leukemia and other malignancies.Chronic myeloid leukemia: advances in understanding disease biology and mechanisms of resistance to tyrosine kinase inhibitors.Targeting non-receptor tyrosine kinases using small molecule inhibitors: an overview of recent advances.Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.Allosteric Communication Networks in Proteins Revealed through Pocket Crosstalk AnalysisHybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase.Allosteric BCR-ABL inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukemia: novel opportunities for drug combinations to overcome resistance.Identification and characterization of activating ABL1 1b kinase mutations: impact on sensitivity to ATP-competitive and allosteric ABL1 inhibitors.Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching.Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.Detection of allosteric kinase inhibitors by displacement of active site probes.An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.Allosterische Kinaseinhibitoren
P2860
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P2860
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@ast
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@en
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@nl
type
label
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@ast
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@en
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@nl
prefLabel
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@ast
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@en
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@nl
P2093
P2860
P1433
P1476
Allosteric interactions between the myristate- and ATP-site of the Abl kinase
@en
P2093
Jianming Zhang
Nathanael S Gray
Roxana E Iacob
P2860
P304
P356
10.1371/JOURNAL.PONE.0015929
P407
P577
2011-01-10T00:00:00Z