Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.
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Principles of allosteric interactions in cell signalingDesigning Allosteric Control into Enzymes by Chemical Rescue of StructureThe Designability of Protein Switches by Chemical Rescue of Structure: Mechanisms of Inactivation and ReactivationSimulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsA unified view of "how allostery works"Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe SH2 domain regulates c-Abl kinase activation by a cyclin-like mechanism and remodulation of the hinge motionMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionTowards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational DynamicsAn automated approach to network features of protein structure ensemblesDifferential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.Allosteric pathway identification through network analysis: from molecular dynamics simulations to interactive 2D and 3D graphs.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.The energy landscape analysis of cancer mutations in protein kinasesProbing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.Allosteric communication across the native and mutated KIT receptor tyrosine kinase.Dynamic multiprotein assemblies shape the spatial structure of cell signalingComputational study of the "DFG-flip" conformational transition in c-Abl and c-Src tyrosine kinases.Computational study on the inhibitor binding mode and allosteric regulation mechanism in hepatitis C virus NS3/4A proteinDissecting protein architecture with communication blocks and communicating segment pairs.Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinaseThe spatial structure of cell signaling systems.Harnessing allostery: a novel approach to drug discovery.Molecular mechanisms of asymmetric RAF dimer activation.Allosteric therapies for lung cancer.Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.Structure-functional prediction and analysis of cancer mutation effects in protein kinases.Small-world networks of residue interactions in the Abl kinase complexes with cancer drugs: topology of allosteric communication pathways can determine drug resistance effects.Allosteric Communication Networks in Proteins Revealed through Pocket Crosstalk AnalysisIdentification of the binding site of an allosteric ligand using STD-NMR, docking, and CORCEMA-ST calculationsStructural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors.Structural bioinformatics and protein docking analysis of the molecular chaperone-kinase interactions: towards allosteric inhibition of protein kinases by targeting the hsp90-cdc37 chaperone machinery.PBxplore: a tool to analyze local protein structure and deformability with Protein Blocks.Design of Elastic Networks with Evolutionary Optimized Long-Range Communication as Mechanical Models of Allosteric Proteins.Tackling the cancer signal transduction “labyrinth”: a combinatorial use of biochemical tools with mathematical models will enhance the identification of optimal targets for each molecular defect.
P2860
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P2860
Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Computational modeling of allo ...... aling in ABL and EGFR kinases.
@ast
Computational modeling of allo ...... aling in ABL and EGFR kinases.
@en
type
label
Computational modeling of allo ...... aling in ABL and EGFR kinases.
@ast
Computational modeling of allo ...... aling in ABL and EGFR kinases.
@en
prefLabel
Computational modeling of allo ...... aling in ABL and EGFR kinases.
@ast
Computational modeling of allo ...... aling in ABL and EGFR kinases.
@en
P2860
P1476
Computational modeling of allo ...... aling in ABL and EGFR kinases.
@en
P2093
Anshuman Dixit
P2860
P304
P356
10.1371/JOURNAL.PCBI.1002179
P577
2011-10-06T00:00:00Z