Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect
about
Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cellsPFKFB3 Regulates Oxidative Stress Homeostasis via Its S-Glutathionylation in CancerReduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathwayKinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling PathwayPFKFB3 Control of Cancer Growth by Responding to Circadian Clock OutputsPhosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cellsInhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanismAscorbic acid and a cytostatic inhibitor of glycolysis synergistically induce apoptosis in non-small cell lung cancer cellsPFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric CancerAnalysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.BRCA1 induces major energetic metabolism reprogramming in breast cancer cells.Structure-based design of small-molecule ligands of phosphofructokinase-2 activating or inhibiting glycolysis.Anticancer agents that counteract tumor glycolysis.Targeting the metabolic microenvironment of tumors.Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism.A novel inhibitor of Mammalian triosephosphate isomerase found by an in silico approach.Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pHRegulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism.
P2860
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P2860
Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structure-based development of ...... s targeting the Warburg effect
@ast
Structure-based development of ...... s targeting the Warburg effect
@en
Structure-based development of ...... s targeting the Warburg effect
@nl
type
label
Structure-based development of ...... s targeting the Warburg effect
@ast
Structure-based development of ...... s targeting the Warburg effect
@en
Structure-based development of ...... s targeting the Warburg effect
@nl
prefLabel
Structure-based development of ...... s targeting the Warburg effect
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Structure-based development of ...... s targeting the Warburg effect
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Structure-based development of ...... s targeting the Warburg effect
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P2093
P2860
P3181
P1433
P1476
Structure-based development of ...... s targeting the Warburg effect
@en
P2093
David Neau
Inder Sehgal
Jeong-Do Kim
Minsuh Seo
Yong-Hwan Lee
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0024179
P407
P577
2011-01-01T00:00:00Z