Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.
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Ten things you should know about protein kinases: IUPHAR Review 14Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionParalog-Specific Patterns of Structural Disorder and Phosphorylation in the Vertebrate SH3-SH2-Tyrosine Kinase Protein Family.Molecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Pseudokinases: update on their functions and evaluation as new drug targets.Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 InhibitorDirect Chemical Activation of a Rationally Engineered Signaling EnzymeComputational Tools for Allosteric Drug Discovery: Site Identification and Focus Library Design.Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks.Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.Structural characterization of nonactive site, TrkA-selective kinase inhibitors.A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase AAllosteric modulators of MEK1: drug design and discovery.Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design.Phosphorylation, Signaling, and Cancer: Targets and Targeting.Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.Biochemical Machines for the Interconversion of Mutual Information and Work.19F-NMR-Based Dual-Site Reporter Assay for the Discovery and Distinction of Catalytic and Allosteric Kinase Inhibitors.Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approachA therapeutic approach to pantothenate kinase associated neurodegeneration
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P2860
Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Novel approaches for targeting ...... activation and pseudokinases.
@en
Novel approaches for targeting ...... activation and pseudokinases.
@nl
type
label
Novel approaches for targeting ...... activation and pseudokinases.
@en
Novel approaches for targeting ...... activation and pseudokinases.
@nl
prefLabel
Novel approaches for targeting ...... activation and pseudokinases.
@en
Novel approaches for targeting ...... activation and pseudokinases.
@nl
P2860
P356
P1476
Novel approaches for targeting ...... activation and pseudokinases.
@en
P2093
Sandra W Cowan-Jacob
Wolfgang Jahnke
P2860
P304
P356
10.4155/FMC.13.216
P50
P577
2014-04-01T00:00:00Z