Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
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The bromodomain: from epigenome reader to druggable targetProtein lysine acetylation by p300/CBPA Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA ProteinsAltering murine leukemia virus integration through disruption of the integrase and BET protein family interactionTargeting bromodomains: epigenetic readers of lysine acetylationChemical probes targeting epigenetic proteins: Applications beyond oncology.Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistenceMerkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus.Phosphorylation of large T antigen regulates merkel cell polyomavirus replicationSurvey for human polyomaviruses in cancer.Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.Brd4 is displaced from HPV replication factories as they expand and amplify viral DNAPhosphorylation of Merkel cell polyomavirus large tumor antigen at serine 816 by ATM kinase induces apoptosis in host cells.Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4.The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA ReplicationIdentifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection.Current understanding of the role of the Brd4 protein in the papillomavirus lifecycle.Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation.Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.Host DNA damage response factors localize to merkel cell polyomavirus DNA replication sites to support efficient viral DNA replication.High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.Merkel cell polyomavirus and Merkel cell carcinoma.A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association.Polyomavirus and Naturally Occuring Neuroglial Tumors in Raccoons (Procyon Lotor).The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC.Fluorescence in situ hybridization and qPCR to detect Merkel cell polyomavirus physical status and load in Merkel cell carcinomas.Merkel cell polyomavirus-positive Merkel cell carcinoma requires viral small T-antigen for cell proliferation.Merkel Cell Polyomavirus: A New DNA Virus Associated with Human Cancer.Merkel cell polyomavirus infection of animal dermal fibroblasts.Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC.Discovery of BET bromodomain inhibitors and their role in target validation
P2860
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P2860
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
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2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@ast
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@en
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@nl
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Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@ast
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@en
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@nl
prefLabel
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@ast
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@en
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@nl
P2093
P2860
P3181
P1433
P1476
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication
@en
P2093
Jianxin You
Rachel M Schowalter
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1003021
P407
P577
2012-11-08T00:00:00Z