Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
about
The role of DNA polymerase activity in human non-homologous end joiningIn vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complexCrucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repairPhosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinaseA high-throughput scintillation proximity-based assay for human DNA ligase IVMechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancerKu recruits the XRCC4-ligase IV complex to DNA endsPartial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in ArtemisGrowth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASGOncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switchingCrystal structure of the Xrcc4 DNA repair protein and implications for end joiningNbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complexFunctional redundancy between DNA ligases I and III in DNA replication in vertebrate cellsEukaryotic DNA ligases: structural and functional insightsAntisense-mediated decrease in DNA ligase III expression results in reduced mitochondrial DNA integrityMutations in PNKP cause microcephaly, seizures and defects in DNA repairLymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombinationGenetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombinationDynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocationsATP-dependent DNA ligasesNon-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor.Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation ExposureModeling the study of DNA damage responses in miceAlternative Okazaki Fragment Ligation Pathway by DNA Ligase IIIAtaxia-telangiectasia: future prospectsRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationStructure of the Catalytic Region of DNA Ligase IV in Complex with an Artemis Fragment Sheds Light on Double-Strand Break RepairEfficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway.53BP1 regulates DSB repair using Rif1 to control 5' end resectionMicrohomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunctionInteractions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinaseSubstrate specificities and identification of putative substrates of ATM kinase family membersDNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformationThe biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotesDNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining systemDeletion of Ku86 causes early onset of senescence in miceTerminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone
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P2860
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
description
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1998
@ast
scientific journal article
@en
vedecký článok (publikovaný 1998/11/12)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/11/12)
@nl
наукова стаття, опублікована в листопаді 1998
@uk
научни чланак (објављен 1998/11/12)
@sr
name
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@ast
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@en
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@nl
type
label
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@ast
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@en
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@nl
prefLabel
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@ast
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@en
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@nl
P2093
P2860
P3181
P356
P1433
P1476
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
@en
P2093
G. A. Rathbun
H. L. Cheng
J. M. Sekiguchi
K. J. Seidl
K. M. Frank
L. Davidson
L. Kangaloo
P2860
P2888
P304
P3181
P356
10.1038/24172
P407
P577
1998-11-12T00:00:00Z
P6179
1003760791