Substrate specificities and identification of putative substrates of ATM kinase family members - Test2 - elhamkhani - TriplyDB

Substrate specificities and identification of putative substrates of ATM kinase family members

Substrate specificities and identification of putative substrates of ATM kinase family members

http://www.wikidata.org/entity/Q28141080

about

ATM-dependent phosphorylation of nibrin in response to radiation exposure Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks Chk2 activation dependence on Nbs1 after DNA damage Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage ATMIN defines an NBS1-independent pathway of ATM signalling Regulation of TIP60 by ATF2 modulates ATM activation ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex A role for DEAD box 1 at DNA double-strand breaks DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3 Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase BAP1 is phosphorylated at serine 592 in S-phase following DNA damage PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints Human MMS21/NSE2 is a SUMO ligase required for DNA repair UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention miRNA response to DNA damage Multiple roles of ATM in monitoring and maintaining DNA integrity Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures Mitochondrial dysfunction in ataxia-telangiectasia The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1 Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

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Substrate specificities and identification of putative substrates of ATM kinase family members

http://www.wikidata.org/entity/Q28141080

description

1999 nî lūn-bûn

@nan

1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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Substrate specificities and id ...... s of ATM kinase family members

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JBC.274.53.37538

P1433

Journal of Biological Chemistry

P1476

Substrate specificities and id ...... s of ATM kinase family members

@en

P2093

C E Canman

http://www.w3.org/2001/XMLSchema#string

D S Lim

http://www.w3.org/2001/XMLSchema#string

M B Kastan

http://www.w3.org/2001/XMLSchema#string

S T Kim

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

ATM binds to beta-adaptin in cytoplasmic vesicles

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints.

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

Association of BRCA1 with Rad51 in mitotic and meiotic cells

The DNA-dependent protein kinase

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

P304

37538-43

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scholarly article

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1433501

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10.1074/JBC.274.53.37538

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53

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274

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1999-12-31T00:00:00Z

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51355041

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10608806

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