Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
about
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiaDifferential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineagesTranscription factor-mediated reprogramming toward hematopoietic stem cellsThe TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursorsDefining an EPOR- regulated transcriptome for primary progenitors, including Tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formationAngiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cellsGata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.Critical requirement of GABPalpha for normal T cell developmentFine-scale staging of T cell lineage commitment in adult mouse thymus.Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.LYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner.A transcriptional mechanism integrating inputs from extracellular signals to activate hippocampal stem cells.E proteins and the regulation of early lymphocyte developmentRequirement for ssbp2 in hematopoietic stem cell maintenance and stress responseBuilding multifunctionality into a complex containing master regulators of hematopoiesis.Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice.GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsRole of helix-loop-helix proteins during differentiation of erythroid cells.Identification of genes differentially expressed in myogenin knock-down bovine muscle satellite cells during differentiation through RNA sequencing analysis.Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells.The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability.Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardiumLmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemiaHematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors.Transcriptional mechanisms underlying hemoglobin synthesis.Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.Ldb1 complexes: the new master regulators of erythroid gene transcription.LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.Genetic interaction between Kit and Scl.Multilayered specification of the T-cell lineage fate.Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.The biochemistry of hematopoietic stem cell development.LIM-domain-only proteins in cancer.Epigenetic and genetic mechanisms in red cell biology.
P2860
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P2860
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
description
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Februar 2009 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2009/02/06)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/02/06)
@nl
наукова стаття, опублікована в лютому 2009
@uk
مقالة علمية (نشرت في 6-2-2009)
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name
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@ast
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@en
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@nl
type
label
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@ast
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@en
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@nl
prefLabel
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@ast
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@en
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@nl
P2093
P2860
P1433
P1476
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
@en
P2093
David J. Curtis
George P. Souroullas
Jessica M. Salmon
Margaret A. Goodell
P2860
P304
P356
10.1016/J.STEM.2009.01.001
P407
P577
2009-02-06T00:00:00Z