Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development - Test2 - elhamkhani - TriplyDB

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

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Similarities and differences in structure, expression, and functions of VLDLR and ApoER2 Structural basis for polyproline recognition by the FE65 WW domain Molecular and functional properties of P2X receptors--recent progress and persisting challenges Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1 The amyloid precursor protein: beyond amyloid FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.Crystal structure of the human Fe65-PTB1 domain Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2 Mutations in DCHS1 cause mitral valve prolapse Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth FE65 as a link between VLDLR and APP to regulate their trafficking and processing Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks A role for FE65 in controlling GnRH-1 neurogenesis.Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.Using evolutionary conserved modules in gene networks as a strategy to leverage high throughput gene expression queries Secreted amyloid precursor protein β and secreted amyloid precursor protein α induce axon outgrowth in vitro through Egr1 signaling pathway Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform.Copper binding to the Alzheimer's disease amyloid precursor protein Follicular fluid Aβ40 concentrations may be associated with ongoing pregnancy following in vitro fertilization Turnover of amyloid precursor protein family members determines their nuclear signaling capability Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth.Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing.A genetic interaction between the APP and Dab1 genes influences brain development.Novel modulators of amyloid-beta precursor protein processing.Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease.An allelic series at the paired box gene 6 (Pax6) locus reveals the functional specificity of Pax genes.Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease.Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65.Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity.Biology and pathophysiology of the amyloid precursor protein.APP physiological and pathophysiological functions: insights from animal models.

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Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

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The EMBO Journal

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Christopher B Eckman

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Elizabeth A Eckman

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James A Richardson

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Joachim Herz

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Robert E Hammer

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Suzanne Guénette

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Thomas Hiesberger

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Yang Chang

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Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains

Perlecan maintains the integrity of cartilage and some basement membranes

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1

Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

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