Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
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TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary ciliaPrimary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengersZfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium FunctionThe IFT-A complex regulates Shh signaling through cilia structure and membrane protein traffickingGenome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental diseaseAP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesisPkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb DevelopmentCauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndromeArl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteinsBiased Polyphenism in Polydactylous Cats Carrying a Single Point Mutation: The Hemingway Model for Digit NoveltyThe tubby family proteins.Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal.Genetics and development of neural tube defects.Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridgeScoring a backstage pass: mechanisms of ciliogenesis and ciliary access.The relationship between sonic Hedgehog signaling, cilia, and neural tube defectsGene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cellsC-terminally mutated tubby protein accumulates in aggresomes.The primary cilium as a Hedgehog signal transduction machine.Primary cilia and graded Sonic Hedgehog signaling.G-protein-coupled receptors, Hedgehog signaling and primary cilia.Stretching cell morphogenesis during late neurulation and mild neural tube defects.The primary cilium as a cellular receiver: organizing ciliary GPCR signalingVariants in TNIP1, a regulator of the NF-kB pathway, found in two patients with neural tube defects.Motile and non-motile cilia in human pathology: from function to phenotypes.Primary Cilia and Mammalian Hedgehog Signaling.Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.Variable expressivity of ciliopathy neurological phenotypes that encompass Meckel-Gruber syndrome and Joubert syndrome is caused by complex de-regulated ciliogenesis, Shh and Wnt signalling defects.The emerging roles of phosphatases in Hedgehog pathway.Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.What are those cilia doing in the neural tube?Lipid metabolism fattens up hedgehog signaling.The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner.APC sets the Wnt tone necessary for cerebral cortical progenitor development.Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.TULP3 is required for GPR161 localization in the ciliumG-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning.A critical role of noggin in developing folate-nonresponsive NTD in Fkbp8 -/- embryos.
P2860
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P2860
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway
description
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Mai 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/05/15)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/05/15)
@nl
наукова стаття, опублікована в травні 2009
@uk
مقالة علمية (نشرت في 15-5-2009)
@ar
name
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@ast
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@en
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@nl
type
label
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@ast
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@en
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@nl
prefLabel
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@ast
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@en
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@nl
P2093
P2860
P921
P3181
P356
P1476
Mouse hitchhiker mutants have ...... of the Sonic hedgehog pathway
@en
P2093
Anju Paudyal
Benjamin Reeve
Christine Damrau
Debbie J Williams
Jennifer N Murdoch
Michelle E Stewart
Pam Siggers
Victoria L Patterson
P2860
P304
P3181
P356
10.1093/HMG/DDP075
P577
2009-02-17T00:00:00Z