Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
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alpha-Synuclein and neuronal cell deathMisfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathiesBeta-synuclein gene alterations in dementia with Lewy bodies.Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred miceDefinition of a molecular pathway mediating α-synuclein neurotoxicityα-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formationAlpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons DiseasePhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Novel subcellular localization for α-synuclein: possible functional consequencesGenetically engineered mouse models of Parkinson's diseasePathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseNeuropathology in mice expressing mouse alpha-synucleinAge-dependent effects of A53T alpha-synuclein on behavior and dopaminergic functionImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceThe Synaptic Function of α-SynucleinThe contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseParkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathyAcyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolismSolid-state ¹³C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-SynucleinPhosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactionsA novel instrumented multipeg running wheel system, Step-Wheel, for monitoring and controlling complex sequential stepping in miceGenetic mouse models of parkinsonism: strengths and limitations.Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.Evidence for a pathogenic role of different mutations at codon 188 of PRNPDifferential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factorsModulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb.alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms.Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cellsTransglutaminase 2 exacerbates α-synuclein toxicity in mice and yeastEtiology of Parkinson's disease: Genetics and environment revisitedLewy bodies.Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.The endotoxin-induced neuroinflammation model of Parkinson's disease.FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophyAlpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast.
P2860
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P2860
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
description
2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im September 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/09/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/09/01)
@nl
наукова стаття, опублікована у вересні 2000
@uk
مقالة علمية نشرت في سبتمبر 2000 حول موضوع: دماغ
@ar
name
Subcellular localization of wi ...... man and transgenic mouse brain
@ast
Subcellular localization of wi ...... man and transgenic mouse brain
@en
Subcellular localization of wi ...... man and transgenic mouse brain
@nl
type
label
Subcellular localization of wi ...... man and transgenic mouse brain
@ast
Subcellular localization of wi ...... man and transgenic mouse brain
@en
Subcellular localization of wi ...... man and transgenic mouse brain
@nl
prefLabel
Subcellular localization of wi ...... man and transgenic mouse brain
@ast
Subcellular localization of wi ...... man and transgenic mouse brain
@en
Subcellular localization of wi ...... man and transgenic mouse brain
@nl
P2093
P921
P3181
P1476
Subcellular localization of wi ...... man and transgenic mouse brain
@en
P2093
A Schindzielorz
H A Kretzschmar
H Jacobsen
H van Der Putten
P304
P3181
P356
10.1523/JNEUROSCI.20-17-06365.2000
P407
P577
2000-09-01T00:00:00Z