MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine
about
The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genesMBD4 interacts with and recruits USP7 to heterochromatic fociInvolvement of MBD4 inactivation in mismatch repair-deficient tumorigenesisMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesEpigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancerExcision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress.Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.Effects of chronic exposure to arsenic and estrogen on epigenetic regulatory genes expression and epigenetic code in human prostate epithelial cellsUNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.Apoptosis and colorectal cancer.Folate and colorectal cancer in rodents: a model of DNA repair deficiency.Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous RecombinationDNA methylation and systemic lupus erythematosus.Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art.Participation of DNA repair in the response to 5-fluorouracil.Intestinal stem cell injury and protection during cancer therapyAssessment of apoptosis by immunohistochemical markers compared to cellular morphology in ex vivo-stressed colonic mucosa.Tagging polymorphisms of methyl-CpG binding domain 4 and gastric cardiac adenocarcinoma risk in a Chinese population.Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.Kaiso-deficient mice show resistance to intestinal cancer.The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.Loss of methyl-CpG-binding domain protein 2 enhances endothelial angiogenesis and protects mice against hind-limb ischemic injury.Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status.Apoptosis and DNA methylation.The mismatch repair and base excision repair pathways: an opportunity for individualized (personalized) sensitization of cancer therapy.MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis.Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.
P2860
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P2860
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/10/16)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/16)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
مقالة علمية (نشرت في 16-10-2003)
@ar
name
MBD4 deficiency reduces the ap ...... in the murine small intestine
@ast
MBD4 deficiency reduces the ap ...... in the murine small intestine
@en
MBD4 deficiency reduces the ap ...... in the murine small intestine
@nl
type
label
MBD4 deficiency reduces the ap ...... in the murine small intestine
@ast
MBD4 deficiency reduces the ap ...... in the murine small intestine
@en
MBD4 deficiency reduces the ap ...... in the murine small intestine
@nl
prefLabel
MBD4 deficiency reduces the ap ...... in the murine small intestine
@ast
MBD4 deficiency reduces the ap ...... in the murine small intestine
@en
MBD4 deficiency reduces the ap ...... in the murine small intestine
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
MBD4 deficiency reduces the ap ...... in the murine small intestine
@en
P2093
Jackie Guy
Joanna Zabkiewicz
Stefan Mark Bishop
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1206850
P407
P577
2003-10-16T00:00:00Z
P5875
P6179
1040218254