UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
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DNA glycosylases: in DNA repair and beyondBase excision repairRegulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.The effect of Pot1 binding on the repair of thymine analogs in a telomeric DNA sequenceCheckpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stressSingle-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models.Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombinationSynergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells.A fatal combination: a thymidylate synthase inhibitor with DNA damaging activity.Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination.Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous RecombinationPredictive markers for the response to 5-fluorouracil therapy in cancer cells: Constant-field gel electrophoresis as a tool for prediction of response to 5-fluorouracil-based chemotherapy.5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.DNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias.Preventive DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate pool.TAS-102, a novel antitumor agent: a review of the mechanism of action.Methoxyamine Enhances 5-Fluorouracil-Induced Radiosensitization in Colon Cancer Cell Line HT29.Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.Evaluation of the Cytotoxic Effects of Hyperthermia and 5-Fluorouracil Loaded Magnetic Nanoparticles on Human Colon Cancer Cell Line HT-29.Quality control of chemically damaged RNA.5-Fluorouracil affects assembly of stress granules based on RNA incorporation.Targeting nuclear thymidylate biosynthesis.Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.Translational reprogramming of colorectal cancer cells induced by 5-fluorouracil through a miRNA-dependent mechanism.dUTPase inhibition augments replication defects of 5-Fluorouracil.Factors affecting the sensitivity of human-derived esophageal carcinoma cell lines to 5-fluorouracil and cisplatin.DNA replication stress and cancer chemotherapy.Differential role of base excision repair proteins in mediating cisplatin cytotoxicity.Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
P2860
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P2860
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
UNG-initiated base excision re ...... s mainly on RNA incorporation.
@ast
UNG-initiated base excision re ...... s mainly on RNA incorporation.
@en
type
label
UNG-initiated base excision re ...... s mainly on RNA incorporation.
@ast
UNG-initiated base excision re ...... s mainly on RNA incorporation.
@en
prefLabel
UNG-initiated base excision re ...... s mainly on RNA incorporation.
@ast
UNG-initiated base excision re ...... s mainly on RNA incorporation.
@en
P2093
P2860
P50
P356
P1476
UNG-initiated base excision re ...... s mainly on RNA incorporation.
@en
P2093
Berit Doseth
Bodil Kavli
Eva K Svaasand
Henrik Sahlin Pettersen
P2860
P304
P356
10.1093/NAR/GKR563
P407
P577
2011-07-10T00:00:00Z