Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families
about
Mast cell mediators: their differential release and the secretory pathways involvedActive monomers of human beta-tryptase have expanded substrate specificitiesHuman subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutationsTryptase genetics and anaphylaxisUrokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levelsThe multifaceted mast cell in inflammatory bowel diseaseProstasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patternsMutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells.Definition of the extended substrate specificity determinants for beta-tryptases I and II.Origin of the murine implantation serine proteinase subfamily.Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain.Mast cell peptidases: chameleons of innate immunity and host defense.Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.Involvement of mast cells in eosinophilic esophagitis.Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitisGenetic deficiency of human mast cell alpha-tryptase.Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transA genomic perspective on human proteases.Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line.A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.Mast cell proteases as pharmacological targetsTissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut.Mast cell tryptases and chymases in inflammation and host defense.Serum tryptase monitoring in indolent systemic mastocytosis: association with disease features and patient outcomeA simple, sensitive and safe method to determine the human α/β-tryptase genotypeProstasin: An Epithelial Sodium Channel Regulator.Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cellsBiology of mast cell tryptase. An inflammatory mediator.Potential effector and immunoregulatory functions of mast cells in mucosal immunity.Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebratesA Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.Regulation of the epithelial Na+ channel by peptidases.Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity.Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Membrane-anchored serine proteases in health and disease.Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation
P2860
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P2860
Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families
description
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Juni 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/06/15)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/06/15)
@nl
наукова стаття, опублікована в червні 2000
@uk
مقالة علمية (نشرت في 15-6-2000)
@ar
name
Characterization of human gamm ...... se and prostasin gene families
@ast
Characterization of human gamm ...... se and prostasin gene families
@en
Characterization of human gamm ...... se and prostasin gene families
@nl
type
label
Characterization of human gamm ...... se and prostasin gene families
@ast
Characterization of human gamm ...... se and prostasin gene families
@en
Characterization of human gamm ...... se and prostasin gene families
@nl
prefLabel
Characterization of human gamm ...... se and prostasin gene families
@ast
Characterization of human gamm ...... se and prostasin gene families
@en
Characterization of human gamm ...... se and prostasin gene families
@nl
P2093
P1476
Characterization of human gamm ...... se and prostasin gene families
@en
P2093
G. H. Caughey
G. M. Verghese
J. L. Blount
M. Pallaoro
P. J. Wolters
W. W. Raymond
P304
P356
10.4049/JIMMUNOL.164.12.6566
P407
P577
2000-06-15T00:00:00Z