Definition of the extended substrate specificity determinants for beta-tryptases I and II.
about
Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutationsExtended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificityMouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patternsHuman tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells.Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site.Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancersThe caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.Defining the extended substrate specificity of kallikrein 1-related peptidases.Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidasesA sequence and structure based method to predict putative substrates, functions and regulatory networks of endo proteases.Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF actionMast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogenMast cell-restricted tryptases: structure and function in inflammation and pathogen defense.Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates.A novel bioluminescent protease assay using engineered firefly luciferase.Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.Modulation of procaspase-7 self-activation by PEST amino acid residues of the N-terminal prodomain and intersubunit linker.Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer.
P2860
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P2860
Definition of the extended substrate specificity determinants for beta-tryptases I and II.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Definition of the extended sub ...... s for beta-tryptases I and II.
@ast
Definition of the extended sub ...... s for beta-tryptases I and II.
@en
type
label
Definition of the extended sub ...... s for beta-tryptases I and II.
@ast
Definition of the extended sub ...... s for beta-tryptases I and II.
@en
prefLabel
Definition of the extended sub ...... s for beta-tryptases I and II.
@ast
Definition of the extended sub ...... s for beta-tryptases I and II.
@en
P2093
P2860
P356
P1476
Definition of the extended sub ...... s for beta-tryptases I and II.
@en
P2093
Haak-Frendscho M
P2860
P304
34941-34947
P356
10.1074/JBC.M102997200
P407
P577
2001-07-03T00:00:00Z