Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity
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Ensuring transmission through dynamic host environments: host-pathogen interactions in Plasmodium sexual developmentOpen Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondMuddled mechanisms: recent progress towards antimalarial target identificationA New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug DiscoveryIsoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition.A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compoundsA semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes.Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte developmentIn Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparumPlasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050.Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes.Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay.A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions.A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs.Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules.Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin.Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and a
P2860
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P2860
Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity
description
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2014年の論文
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2014年論文
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name
Gametocytocidal screen identif ...... transmission blocking activity
@ast
Gametocytocidal screen identif ...... transmission blocking activity
@en
Gametocytocidal screen identif ...... transmission blocking activity
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type
label
Gametocytocidal screen identif ...... transmission blocking activity
@ast
Gametocytocidal screen identif ...... transmission blocking activity
@en
Gametocytocidal screen identif ...... transmission blocking activity
@nl
prefLabel
Gametocytocidal screen identif ...... transmission blocking activity
@ast
Gametocytocidal screen identif ...... transmission blocking activity
@en
Gametocytocidal screen identif ...... transmission blocking activity
@nl
P2093
P2860
P3181
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P1476
Gametocytocidal screen identif ...... transmission blocking activity
@en
P2093
Abhai K Tripathi
David J Sullivan
George Dimopoulos
Godfree Mlambo
Natalie G Sanders
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0105817
P407
P577
2014-01-01T00:00:00Z