Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies
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Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.Native-like Env trimers as a platform for HIV-1 vaccine design.Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoproteinEvolution of B cell analysis and Env trimer redesign.Adjuvants: tailoring humoral immune responses.Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.HIV-1 Cross-reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Non-human Primate.Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins.DNA prime/protein boost vaccination elicits robust humoral response in rhesus macaques using oligomeric simian immunodeficiency virus envelope and Advax delta inulin adjuvant.Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at its Apex.Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model.Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice.Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses.Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization.A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers.Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies.Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro.Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodiesStrategies for a multi-stage neutralizing antibody-based HIV vaccine
P2860
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P2860
Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies
description
2016 nî lūn-bûn
@nan
2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@ast
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@en
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@nl
type
label
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@ast
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@en
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@nl
prefLabel
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@ast
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@en
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@nl
P2093
P2860
P3181
P1433
P1476
Thermostability of Well-Ordere ...... Tier 2 Neutralizing Antibodies
@en
P2093
Andrew B Ward
Heather Arendt
Javier Guenaga
Joanne DeStefano
Karen Tran
Natalia de Val
Richard T Wyatt
Richard Wilson
Shailendra Kumar
Shridhar Bale
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1005767
P407
P50
P577
2016-08-01T00:00:00Z