Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
about
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domainsEvolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding propertiesStructure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter releaseCalcium control of neurotransmitter releaseStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter releaseCrystal structure of the RIM1alpha C2B domain at 1.7 A resolutionGenetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosisThe functional significance of synaptotagmin diversity in neuroendocrine secretionGlial cells in (patho)physiologyThe C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3ASynaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosisUpregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdownInjured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cellsRelease mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cellsRat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusionSynaptotagmin-11 inhibits clathrin-mediated and bulk endocytosisSynaptotagmin IV modulation of vesicle size and fusion pores in PC12 cellsSynaptotagmin IV: a multifunctional regulator of peptidergic nerve terminalsSinging, but not seizure, induces synaptotagmin IV in zebra finch song circuit nuclei.Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.Cross-linking of phospholipid membranes is a conserved property of calcium-sensitive synaptotagminsLoss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neuronsPost-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1SNAREs Controlling Vesicular Release of BDNF and Development of Callosal Axons.Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin.Enlightening molecular mechanisms through study of protein interactionsPostsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons.Neurotransmitters and integration in neuronal-astroglial networks.Exocytosis and synaptic vesicle function.Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin IThe Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathwaySynaptotagmin-7 links fusion-activated Ca²⁺ entry and fusion pore dilation.The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides.Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia.Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking.Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.
P2860
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P2860
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
description
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
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im September 2004 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2004/09/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/09/01)
@nl
наукова стаття, опублікована у вересні 2004
@uk
مقالة علمية (نشرت في سبتمبر 2004)
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name
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@ast
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@en
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@nl
type
label
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@ast
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@en
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@nl
prefLabel
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@ast
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@en
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@nl
P2860
P50
P3181
P356
P1476
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/NSMB817
P577
2004-09-01T00:00:00Z
P5875
P6179
1011339243