Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranes
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Crystal Structure of a Mammalian CTP: Phosphocholine Cytidylyltransferase Catalytic Domain Reveals Novel Active Site Residues within a Highly Conserved Nucleotidyltransferase FoldStructural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic HelixThree-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranesFunctions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cellsExpansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha.Nuclear export of the rate-limiting enzyme in phosphatidylcholine synthesis is mediated by its membrane binding domain.Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry.HAMLET interacts with lipid membranes and perturbs their structure and integrity.Diversity and versatility of lipid-protein interactions revealed by molecular genetic approaches.Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase.The peripheral binding of 14-3-3γ to membranes involves isoform-specific histidine residues.Probing the interaction of brain fatty acid binding protein (B-FABP) with model membranesAlpha-synuclein function and dysfunction on cellular membranes.The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner.The N-terminal amphipathic region of the Escherichia coli type III secretion system protein EspD is required for membrane insertion and functionCell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues.Infectious Disease: Connecting Innate Immunity to Biocidal Polymers.Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayersStructural dynamics of soluble chloride intracellular channel protein CLIC1 examined by amide hydrogen-deuterium exchange mass spectrometry.Interactions of amelogenin with phospholipids.The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulumA 22-mer segment in the structurally pliable regulatory domain of metazoan CTP: phosphocholine cytidylyltransferase facilitates both silencing and activating functions.The intrinsically disordered nuclear localization signal and phosphorylation segments distinguish the membrane affinity of two cytidylyltransferase isoforms.Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies.Virus-like particles from Escherichia Coli-derived untagged papaya ringspot virus capsid protein purified by immobilized metal affinity chromatography enhance the antibody response against a soluble antigen.Pore-forming Activity of the Escherichia coli Type III Secretion System Protein EspD.Contribution of each membrane binding domain of the CTP:phosphocholine cytidylyltransferase-alpha dimer to its activation, membrane binding, and membrane cross-bridging.Effects of phospholipid composition on MinD-membrane interactions in vitro and in vivo.Identification and in silico analysis of helical lipid binding regions in proteins belonging to the amphitropic protein family.Relevance of the protein macrodipole in the membrane-binding process. Interactions of fatty-acid binding proteins with cationic lipid membranes.Phosphoenolpyruvate carboxylase from C4 leaves is selectively targeted for inhibition by anionic phospholipids.
P2860
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P2860
Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranes
description
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im Januar 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/01/03)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/01/03)
@nl
наукова стаття, опублікована в січні 2003
@uk
name
Both acidic and basic amino ac ...... ectivity for anionic membranes
@ast
Both acidic and basic amino ac ...... ectivity for anionic membranes
@en
Both acidic and basic amino ac ...... ectivity for anionic membranes
@nl
type
label
Both acidic and basic amino ac ...... ectivity for anionic membranes
@ast
Both acidic and basic amino ac ...... ectivity for anionic membranes
@en
Both acidic and basic amino ac ...... ectivity for anionic membranes
@nl
prefLabel
Both acidic and basic amino ac ...... ectivity for anionic membranes
@ast
Both acidic and basic amino ac ...... ectivity for anionic membranes
@en
Both acidic and basic amino ac ...... ectivity for anionic membranes
@nl
P2093
P2860
P356
P1476
Both acidic and basic amino ac ...... ectivity for anionic membranes
@en
P2093
Joanne E. Johnson
Laila M. R. Singh
Mingtang Xie
Robert Edge
Rosemary B. Cornell
P2860
P304
P356
10.1074/JBC.M206072200
P407
P577
2003-01-03T00:00:00Z