Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
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3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteinsSmad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their CrosstalksTGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formationNatural history of β-cell adaptation and failure in type 2 diabetesNon-Smad pathways in TGF-beta signalingReciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells.MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal plasticity in normal murine mammary gland cellsImmunoregulatory functions of mTOR inhibition.The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation.Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.DHT selectively reverses Smad3-mediated/TGF-beta-induced responses through transcriptional down-regulation of Smad3 in prostate epithelial cellsThe S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc.Critical role of a survivin/TGF-β/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cellsNodal and lefty signaling regulates the growth of pancreatic cellsTGF-β inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II.Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)Tight junction protein 1 is regulated by transforming growth factor-β and contributes to cell motility in NSCLC cells.CCN2 requires TGF-β signalling to regulate CCAAT/enhancer binding proteins and inhibit fat cell differentiation.Transforming growth factor-β1 regulated phosphorylated AKT and interferon gamma expressions are associated with epithelial cell survival in rhesus macaque colon explants.Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signalingFenofibrate enhances the in vitro differentiation of foxp3(+) regulatory T cells in miceRegulation and function of mTOR signalling in T cell fate decisions.Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells.Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.Investigating mammalian target of rapamycin inhibitors for their anticancer properties.A Signaling Network Controlling Androgenic Repression of c-Fos Protein in Prostate Adenocarcinoma Cells.mTOR at the crossroads of T cell proliferation and tolerance.Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest.FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury.Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling PathwayRoles of Smad3 in TGF-beta signaling during carcinogenesis.Sirolimus-associated infertility: case report and literature review of possible mechanisms.Androgenic control of transforming growth factor-beta signaling in prostate epithelial cells through transcriptional suppression of transforming growth factor-beta receptor II.Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesisMammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignanciesThe type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2.Identification of a novel negative regulator of activin/nodal signaling in mesendodermal formation of Xenopus embryos.Signaling cross-talk between TGF-beta/BMP and other pathways.
P2860
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P2860
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@ast
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@en
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@nl
type
label
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@ast
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@en
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@nl
prefLabel
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@ast
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@en
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@nl
P2093
P2860
P3181
P356
P1433
P1476
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
@en
P2093
David Danielpour
Kyung Song
Tracy L Krebs
P2860
P3181
P356
10.1038/SJ.EMBOJ.7600917
P407
P577
2005-12-15T00:00:00Z