Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues
about
Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1Plasma membrane transporters in modern liver pharmacologyReduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug ResistanceNucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes.FUN26 (function unknown now 26) protein from saccharomyces cerevisiae is a broad selectivity, high affinity, nucleoside and nucleobase transporter.Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocationCloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell lineMolecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brainIdentification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitorsInhibiting the growth of pancreatic adenocarcinoma in vitro and in vivo through targeted treatment with designer gold nanotherapeuticsImmunocytochemical demonstration of the equilibrative nucleoside transporter rENT1 in rat sinoatrial nodeControl of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1Nucleoside transporter subtype expression and function in rat skeletal muscle microvascular endothelial cellsChronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transportThe role of adenosine A2A and A3 receptors on the differential modulation of norepinephrine and neuropeptide Y release from peripheral sympathetic nerve terminalsIdentification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression.Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues.Identification of rat lung--prominent genes by a parallel DNA microarray hybridizationThe type 1 equilibrative nucleoside transporter regulates anxiety-like behavior in miceXenobiotic, bile acid, and cholesterol transporters: function and regulation.Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms.Implication of the purinergic system in alcohol use disorders.Host-based ribavirin resistance influences hepatitis C virus replication and treatment response.Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).The effect of eplerenone on adenosine formation in humans in vivo: a double-blinded randomised controlled study.Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy.Challenges for the development of ribonucleoside analogues as inducers of error catastrophe.Nucleoside and nucleobase transporters in parasitic protozoa.Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity.Residue Ile89 in human plasma membrane monoamine transporter influences its organic cation transport activity and sensitivity to inhibition by dilazepCloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutantExtracellular guanosine regulates extracellular adenosine levels.Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injuryRoles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro.Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4).Adenosine signaling in striatal circuits and alcohol use disorders.
P2860
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P2860
Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues
description
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im November 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/11/07)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/11/07)
@nl
наукова стаття, опублікована в листопаді 1997
@uk
name
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@ast
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@en
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@nl
type
label
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@ast
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@en
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@nl
prefLabel
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@ast
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@en
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@nl
P2093
P356
P1476
Molecular cloning and function ...... T1 and rENT2) from rat tissues
@en
P2093
C. E. Cass
J. D. Young
M. Griffiths
S. A. Baldwin
W. R. Muzyka
P304
28423–28430
P356
10.1074/JBC.272.45.28423
P407
P577
1997-11-07T00:00:00Z