Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
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Recent advances in the pathogenesis of syndromic autismsNeuroligin-1-dependent competition regulates cortical synaptogenesis and synapse numberPhosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalitiesReduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.The tuberous sclerosis complexAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyAmyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryReversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosisRheb and mTOR regulate neuronal polarity through Rap1BThe PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of AutismThe neurology of mTOREpilepsy related to developmental tumors and malformations of cortical developmentCellular and synaptic network defects in autismDendritic spine dysgenesis in autism related disordersPotential for treatment of severe autism in tuberous sclerosis complexMechanisms of TSC-mediated control of synapse assembly and axon guidanceMapping autism risk loci using genetic linkage and chromosomal rearrangements.Searching for signaling balance through the identification of genetic interactors of the Rab guanine-nucleotide dissociation inhibitor gdi-1Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic SignalingA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disordersA new synaptic player leading to autism risk: Met receptor tyrosine kinaseThe ups and downs of Wnt signaling in prevalent neurological disordersTsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagyGene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and Wnt signaling in epileptogenesis.Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitizationTuberous sclerosis complex proteins control axon formationNon-canonical functions of the tuberous sclerosis complex-Rheb signalling axisDendritic spine pathology in neuropsychiatric disordersTricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome ProteinIn vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndromeRas and Rap signaling in synaptic plasticity and mental disorders.Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberinEpac2-mediated dendritic spine remodeling: implications for disease.Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy.The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex.Pten deletion causes mTorc1-dependent ectopic neuroblast differentiation without causing uniform migration defects.Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis.Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
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P248
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P2860
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
description
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Dezember 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/12/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/12/01)
@nl
наукова стаття, опублікована в грудні 2005
@uk
مقالة علمية (نشرت في ديسمبر 2005)
@ar
name
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@ast
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@en
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@nl
type
label
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@ast
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@en
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@nl
prefLabel
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@ast
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@en
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
@en
P2093
Bernardo L Sabatini
David J Kwiatkowski
Dennis A Ridenour
Sohail F Tavazoie
P2860
P2888
P304
P3181
P356
10.1038/NN1566
P407
P577
2005-11-06T00:00:00Z