Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain
about
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3AStructure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain associationPhosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentPhosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-foldCa2+-binding motif of βγ-crystallins.Discovery of novel membrane binding structures and functionsThe juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.Integration of Diverse Research Methods to Analyze and Engineer Ca-Binding Proteins: From Prediction to ProductionA novel missense mutation in the C2C domain of otoferlin causes profound hearing impairment in an Omani family with auditory neuropathy.Cloning, expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of human synaptotagmin 5 C2A domainSolution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridgingConformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling.Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I.Synaptotagmin's role in neurotransmitter release likely involves Ca(2+)-induced conformational transition.Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivoCa2+ regulates the Drosophila Stoned-A and Stoned-B proteins interaction with the C2B domain of Synaptotagmin-1Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin.An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Purification, crystallization and X-ray diffraction analysis of human synaptotagmin 1 C2A-C2BStructure and dynamics of Ca2+-binding domain 1 of the Na+/Ca2+ exchanger in the presence and in the absence of Ca2+The c2 domains of human synaptotagmin 1 have distinct mechanical propertiesRole of calcium in membrane interactions by PI(4,5)P₂-binding proteins.Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions.Distinct roles of the C2A and the C2B domain of the vesicular Ca2+ sensor synaptotagmin 9 in endocrine beta-cells.Drosophila studies support a role for a presynaptic synaptotagmin mutation in a human congenital myasthenic syndrome.Ramachandran analysis of conserved glycyl residues in homologous proteins of known structureHeterogeneous behavior of metalloproteins toward metal ion binding and selectivity: insights from molecular dynamics studies.Nerve-evoked synchronous release and high K+ -induced quantal events are regulated separately by synaptotagmin I at Drosophila neuromuscular junctions.The synaptotagmin C2B domain calcium-binding loops modulate the rate of fusion pore expansion.
P2860
Q26269910-9102A7C4-868C-49E3-9663-326C18E89720Q27643300-A78E98FB-533E-410B-A575-FD683D8BD18AQ27648873-1EAE2FBD-0E24-4D2A-804E-77D3EE5933D6Q27678096-7DEC1591-F43C-4525-BB71-C5996005D8A7Q28577400-DFFF50E0-0EDA-4D03-AE67-7FE3C685EA8CQ30359420-5B464550-5217-4371-B54E-BF79E005EC87Q30368636-0BCA8FAF-3884-4B4E-ADCC-480B183C35CCQ30371438-E0780417-F0CC-4034-86DA-D9005232C738Q30393133-D613CD4D-E223-4C6D-8C2F-89902FDAF02EQ30393203-1FB1CEBB-AEC7-4EDE-B91D-254D0C09B93DQ30409755-D7F54C90-63BF-427F-A662-132F689789E0Q30435374-FCDD16DD-F94F-4E9B-930A-E0B37B678FD1Q30437821-8B1704F4-2FF9-4FE2-A743-5A3995BE3A86Q30525734-2803423F-8B94-4141-BF64-178CEF348428Q34144056-204E6E41-8556-4F4E-9D39-03C69ED2B7F1Q34171564-5AE8F507-0124-4746-B0F3-461B83C5FF60Q34305768-97B07FF7-C6F9-4016-83D0-42854B70C714Q35069723-E201AE5A-D05A-499D-857D-5F60DCE869D7Q35687725-77CEF2EB-D0EC-43F7-9423-B5018102F4CAQ35995925-A8020DA2-40FD-4191-95EC-E6200830A763Q36137565-3AB12D0C-5BB1-4815-8136-D65194B17C03Q36459421-640FCCCE-5F58-4A88-8684-15864BC86E5CQ37243184-0F0B4B65-542E-4122-B586-3E3C9FA3C601Q37277575-46EBCCD1-6EBA-4A78-9A0B-C61AB4032D6DQ38252318-5A5124EE-A28A-4BC3-BC2B-9CFF0242B962Q38749071-17EDADFD-DF30-44CA-BC73-DC69E249E14EQ41774775-FA6D9D67-B6D5-437F-AB0A-FF65637F2D0BQ41836213-AC865600-D400-450B-A20D-D25B3ECEB95BQ41842245-ADC3D214-0F31-4BA1-85A3-402E6B09AC6CQ51819200-A550776A-3591-4F70-95B1-37D0E3B29527Q52673852-04000842-BC23-4088-81CE-096C0FF4731FQ55239707-95AF72EB-B63D-4D74-A68E-F7836B0B1A05
P2860
Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain
description
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Oktober 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/10/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/10/01)
@nl
наукова стаття, опублікована в жовтні 2004
@uk
مقالة علمية (نشرت في أكتوبر 2004)
@ar
name
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@ast
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@en
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@nl
type
label
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@ast
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@en
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@nl
prefLabel
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@ast
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@en
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@nl
P2093
P2860
P3181
P356
P1433
P1476
Crystallographic identificatio ...... in synaptotagmin I C2B domain
@en
P2093
Dinshaw J. Patel
Lucy Malinina
Sonia M. Sequeira
Thomas H. Söllner
Valentina Tereshko
Yuan Cheng
P2860
P304
P3181
P356
10.1110/PS.04832604
P577
2004-10-01T00:00:00Z