Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?
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The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calciumAlternate splicing of dysferlin C2A confers Ca²⁺-dependent and Ca²⁺-independent binding for membrane repairThe diversity of calcium sensor proteins in the regulation of neuronal functionDynamic binding mode of a Synaptotagmin-1-SNARE complex in solutionStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosisAn unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.Distinct initial SNARE configurations underlying the diversity of exocytosisStructure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1.Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interactionA conformational switch in the Piccolo C2A domain regulated by alternative splicingStructural analysis of conserved oligomeric Golgi complex subunit 2Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain associationPb 2+ as Modulator of Protein–Membrane InteractionsSynaptotagmin I functions as a calcium regulator of release probabilityMembrane targeting of C2 domains of phospholipase C-delta isoformsA conformational switch in complexin is required for synaptotagmin to trigger synaptic fusionStructural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid MembranesC2 domains from different Ca2+ signaling pathways display functional and mechanistic diversityStructural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusionCrystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domainSynaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusionC2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound statePtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridgingConformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling.Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cellsCalcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.Amphitropic proteins: regulation by reversible membrane interactions (review).Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions.Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex.Molecular structures of proteins involved in vesicle fusion.Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivoOtoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion.Molecular mechanisms of neurotransmitter release.Single-molecule studies of synaptotagmin and complexin binding to the SNARE complex.
P2860
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P2860
Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Solution structures of the Ca2 ...... nduce a conformational change?
@ast
Solution structures of the Ca2 ...... nduce a conformational change?
@en
Solution structures of the Ca2 ...... nduce a conformational change?
@nl
type
label
Solution structures of the Ca2 ...... nduce a conformational change?
@ast
Solution structures of the Ca2 ...... nduce a conformational change?
@en
Solution structures of the Ca2 ...... nduce a conformational change?
@nl
prefLabel
Solution structures of the Ca2 ...... nduce a conformational change?
@ast
Solution structures of the Ca2 ...... nduce a conformational change?
@en
Solution structures of the Ca2 ...... nduce a conformational change?
@nl
P2093
P3181
P356
P1433
P1476
Solution structures of the Ca2 ...... nduce a conformational change?
@en
P2093
P304
P3181
P356
10.1021/BI981789H
P407
P577
1998-11-17T00:00:00Z