Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
about
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cellsBiomedicine and diseases: the Klippel-Trenaunay syndrome, vascular anomalies and vascular morphogenesisVE-PTP controls blood vessel development by balancing Tie-2 activityVascular endothelial growth factor B, a novel growth factor for endothelial cellsAngiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contactsA novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinasesThe PTEN/PI3K pathway governs normal vascular development and tumor angiogenesisDok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.Biologic significance of angiopoietin-2 expression in human hepatocellular carcinomaDisruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesisThe hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic developmentThe LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesisThe orphan nuclear receptor COUP-TFII is required for angiogenesis and heart developmentRoles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesisEdg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturationGrowth of engineered human myocardium with mechanical loading and vascular cocultureVE-statin, an endothelial repressor of smooth muscle cell migrationA unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and functionDifferential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissueReceptor tyrosine kinase-mediated angiogenesisVascular anomalies: from genetics toward models for therapeutic trialsAngiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.Rapamycin improves TIE2-mutated venous malformation in murine model and human subjectsAngiopoietin-Tie signalling in the cardiovascular and lymphatic systemsCloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptorFunctional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate developmentThe enigmatic role of angiopoietin-1 in tumor angiogenesisAngiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide regionNERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxiaA lymphatic defect causes ocular hypertension and glaucoma in miceHBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic developmentRescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival functionThe Role of PTEN in Tumor AngiogenesisVascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesisUnsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular developmentHOXA13 Is essential for placental vascular patterning and labyrinth endothelial specificationAngiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defenseTranscriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells
P2860
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P2860
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
description
1994 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1994
@ast
im August 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1994/08/15)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/08/15)
@nl
наукова стаття, опублікована в серпні 1994
@uk
مقالة علمية (نشرت في 15-8-1994)
@ar
name
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@ast
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@en
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@nl
type
label
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@ast
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@en
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@nl
prefLabel
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@ast
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@en
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@nl
P2093
P3181
P356
P1433
P1476
Dominant-negative and targeted ...... n vasculogenesis of the embryo
@en
P2093
A Auerbach
D J Dumont
M Gertsenstein
M L Breitman
P304
P3181
P356
10.1101/GAD.8.16.1897
P577
1994-08-01T00:00:00Z