Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation - Test2 - elhamkhani - TriplyDB

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

http://www.wikidata.org/entity/Q28586404

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From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway Inhibition of histone deacetylases in cancer therapy: lessons from leukaemia Acute promyelocytic leukemia: where did we start, where are we now, and the future Controversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects?The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies How animal models of leukaemias have already benefited patients Vitamin A, cancer treatment and prevention: the new role of cellular retinol binding proteins Targeting of leukemia-initiating cells in acute promyelocytic leukemia Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis Pioglitazone together with imatinib in chronic myeloid leukemia: A proof of concept study.Disruption of histone modification and CARM1 recruitment by arsenic represses transcription at glucocorticoid receptor-regulated promoters.Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC Curing all patients with acute promyelocytic leukemia: are we there yet?Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse Endoplasmic reticulum calcium pumps and cancer cell differentiation.Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia.Growth arrest and forced differentiation of human primary glioblastoma multiforme by a novel small molecule.Pin1-Targeted Therapy for Systemic Lupus Erythematosus Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL.Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells.Leukaemogenesis: more than mutant genes Dynamics of leukemia stem-like cell extinction in acute promyelocytic leukemia.PML-mediated signaling and its role in cancer stem cells.MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia.Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome.Personalized medicine and cancer.Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors Deferasirox and vitamin D improves overall survival in elderly patients with acute myeloid leukemia after demethylating agents failure.Effector caspases and leukemia Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.Combination of arsenic and interferon-α inhibits expression of KSHV latent transcripts and synergistically improves survival of mice with primary effusion lymphomas Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein.Phase 1 study of arsenic trioxide, high-dose cytarabine, and idarubicin to down-regulate constitutive signal transducer and activator of transcription 3 activity in patients aged <60 years with acute myeloid leukemia Reactive oxygen species regulate the differentiation of acute promyelocytic leukemia cells through HMGB1-mediated autophagy PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.The APL paradigm and the "co-clinical trial" project.

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Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

http://www.wikidata.org/entity/Q28586404

description

2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2008

@ast

im Dezember 2008 veröffentlichter wissenschaftlicher Artikel

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scientific journal article

@en

vedecký článok (publikovaný 2008/12/01)

@sk

vědecký článek publikovaný v roce 2008

@cs

wetenschappelijk artikel (gepubliceerd op 2008/12/01)

@nl

наукова стаття, опублікована в грудні 2008

@uk

مقالة علمية (نشرت في ديسمبر 2008)

@ar

name

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@ast

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@en

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@nl

type

label

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@ast

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@en

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@nl

prefLabel

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@ast

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

@en

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

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Nature Medicine

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Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

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Bernard Gourmel

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Caroline Berthier

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Cécile Rochette-Egly

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Dominique Vitoux

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Hassan Soilihi

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Jun Zhu

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Laurent Peres

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Macarena Robledo-Sarmiento

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Omar Ferhi

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Philippe Rousselot

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1333–1342

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scholarly article

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3705323

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10.1038/NM.1891

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12

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14

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Marie-Claude Guillemin

Pier Paolo Pandolfi

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2008-12-01T00:00:00Z

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23493879

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19029980

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