Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway - Test2 - elhamkhani - TriplyDB

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

http://www.wikidata.org/entity/Q24623800

about

Pediatric medulloblastoma - update on molecular classification driving targeted therapies Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists The hedgehog pathway in triple-negative breast cancer Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Hedgehog Signaling in Malignant Pleural Mesothelioma Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Hedgehog signaling inhibitors as anti-cancer agents in osteosarcoma Basal cell carcinoma - molecular biology and potential new therapies Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition Potential approaches to the treatment of Ewing's sarcoma In vitro models of cancer stem cells and clinical applications Survival regulation of leukemia stem cells Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6 Small-molecule synthetic compound norcantharidin reverses multi-drug resistance by regulating Sonic hedgehog signaling in human breast cancer cells Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box.VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.Management of pediatric and adult patients with medulloblastoma.Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.Arsenic: a potentially useful poison for Hedgehog-driven cancers.Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges.Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.The hedgehog/Gli signaling paradigm in prostate cancer Integration of Network Biology and Imaging to Study Cancer Phenotypes and Responses.Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization.Hedgehog pathway as a drug target: Smoothened inhibitors in development.Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy.Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth.Cryptotanshinone enhances the effect of Arsenic trioxide in treating liver cancer cell by inducing apoptosis through downregulating phosphorylated- STAT3 in vitro and in vivo.Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI.Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context-Dependent Manner.Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma.From molecular interaction to acute promyelocytic leukemia: Calculating leukemogenesis and remission from endogenous molecular-cellular network.

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Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

http://www.wikidata.org/entity/Q24623800

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

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2011年论文

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name

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@ast

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@en

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@nl

type

label

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@ast

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@en

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@nl

prefLabel

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@ast

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@en

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

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P1433

Journal of Clinical Investigation

P1476

Arsenic trioxide inhibits huma ...... blocking Hedgehog/GLI pathway

@en

P2093

Aykut Uren

http://www.w3.org/2001/XMLSchema#string

Chris Albanese

http://www.w3.org/2001/XMLSchema#string

Daniel Peaceman

http://www.w3.org/2001/XMLSchema#string

Elspeth M Beauchamp

http://www.w3.org/2001/XMLSchema#string

Gülay Bulut

http://www.w3.org/2001/XMLSchema#string

Jeffrey A Toretsky

http://www.w3.org/2001/XMLSchema#string

Kamal P Sajwan

http://www.w3.org/2001/XMLSchema#string

Lymor Ringer

http://www.w3.org/2001/XMLSchema#string

Metin Ozdemirli

http://www.w3.org/2001/XMLSchema#string

Michael D Hall

http://www.w3.org/2001/XMLSchema#string

P2860

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Vertebrate Smoothened functions at the primary cilium.

Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

Specific covalent labeling of recombinant protein molecules inside live cells

Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide

P304

148-60

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scholarly article

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2182453

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P356

10.1172/JCI42874

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P407

P433

1

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P478

121

http://www.w3.org/2001/XMLSchema#string

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2011-01-01T00:00:00Z

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21183792

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3007144

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