Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
about
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPasePCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cellsNuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsDNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancerNSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer CellsDNA repair and cancer: lessons from mutant mouse models.The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanineHuman DNA repair systems: an overview.A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants.Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesisSilencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer.Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer.Promoter methylation status of MGMT, hMSH2, and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma.O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy.Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine.Molecular devices for high fidelity of DNA replication and gene expression.Regulation of DNA repair by S-nitrosylation.Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development.Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteinsMouse models of DNA mismatch repair in cancer research.CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection.Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks.O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development.Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.Mechanisms of tolerance to DNA damaging therapeutic drugs.Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.Resolving the evolutionary paradox of genetic instability: a cost-benefit analysis of DNA repair in changing environments.An intronic genetic variation of affects enhancer activity and is associated with glioma susceptibility
P2860
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P2860
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
description
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1998
@ast
im April 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/04/28)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/04/28)
@nl
наукова стаття, опублікована у квітні 1998
@uk
name
Separation of killing and tumo ...... in two of the DNA repair genes
@ast
Separation of killing and tumo ...... in two of the DNA repair genes
@en
Separation of killing and tumo ...... in two of the DNA repair genes
@nl
type
label
Separation of killing and tumo ...... in two of the DNA repair genes
@ast
Separation of killing and tumo ...... in two of the DNA repair genes
@en
Separation of killing and tumo ...... in two of the DNA repair genes
@nl
prefLabel
Separation of killing and tumo ...... in two of the DNA repair genes
@ast
Separation of killing and tumo ...... in two of the DNA repair genes
@en
Separation of killing and tumo ...... in two of the DNA repair genes
@nl
P2093
P2860
P356
P1476
Separation of killing and tumo ...... in two of the DNA repair genes
@en
P2093
M. Sekiguchi
S. Takahashi
T. Ishikawa
T. Tsuzuki
Y. Nakatsuru
P2860
P304
P356
10.1073/PNAS.95.9.5116
P407
P577
1998-04-28T00:00:00Z