Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
about
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesisKruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesisGata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic developmentThe critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12A novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activityGenomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.Directing oncogenic fusion genes into stem cells via an SCL enhancer.Krüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells.Mapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain.Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells.Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cellsThe SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation.The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.Of lineage and legacy: the development of mammalian hematopoietic stem cellsGreen fluorescent protein transgene driven by Kit regulatory sequences is expressed in hematopoietic stem cells.Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses.Transcriptional regulation of haematopoietic transcription factors.Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sitesEstablishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo.Analysis of multiple genomic sequence alignments: a web resource, online tools, and lessons learned from analysis of mammalian SCL loci.SCL assembles a multifactorial complex that determines glycophorin A expression.Functional but abnormal adult erythropoiesis in the absence of the stem cell leukemia geneCharacterization of a Fetal Liver Cell Population Endowed with Long-Term Multiorgan Endothelial Reconstitution Potential.The SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins.
P2860
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P2860
Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer
description
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Dezember 2001 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2001/12/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/12/01)
@nl
наукова стаття, опублікована в грудні 2001
@uk
مقالة علمية (نشرت في ديسمبر 2001)
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name
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@ast
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@en
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@nl
type
label
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@ast
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@en
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@nl
prefLabel
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@ast
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@en
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@nl
P2093
P1433
P1476
Selective rescue of early haem ...... ontrol of a stem cell enhancer
@en
P2093
A. R. Green
E. O. Bockamp
L. Gambardella
M. J. Sánchez
P304
P407
P577
2001-12-01T00:00:00Z