Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability
about
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinaseThe UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic functionThe BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitinModeling the study of DNA damage responses in miceHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsNuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1Is there more to BARD1 than BRCA1?An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular developmentBARD1 participates with BRCA1 in homology-directed repair of chromosome breaksA homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plantsThe BARD1 Cys557Ser variant and breast cancer risk in IcelandGenome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints.BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility.Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrestThe breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.Ubiquitin and breast cancer.BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation.The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.Age-associated increase in aneuploidy and changes in gene expression in mouse eggsExpression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon CancerE3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinomaRecognition of DNA double strand breaks by the BRCA1 tumor suppressor network.The DNA resection protein CtIP promotes mammary tumorigenesis.Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability.Links between genome integrity and BRCA1 tumor suppression.Alternative splicing in cancer: implications for biology and therapy.Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype.Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks.The Emerging Role of Non-traditional Ubiquitination in Oncogenic Pathways.BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis.Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells.Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis.The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.Dualistic Role of BARD1 in Cancer.BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.BRCA1 forms a heterodimer with BARD1Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer
P2860
Q24298631-F4E780EF-4E59-4853-B10E-9F041313D60BQ24305086-34A0CC34-CE3E-4BC2-BEEE-21DA8162B446Q24312959-2F724FA1-E02A-46CF-9FF2-F0CC42622AE9Q26826949-D4168164-8E8D-4BC3-8BB4-8DDFEC9C0126Q28085364-28872691-F6E9-407C-848B-D99828784B7EQ28188597-A64C7E0F-3FBE-4FD9-A5EC-8674F14BE1FEQ28236135-7736EE95-133F-4D52-BB34-414A97EDBC12Q28587411-65CA367B-797A-4EA0-9B4F-8B19D11AE4A4Q28609933-5F865F04-A8A0-4E07-8C89-0015178453D3Q30478012-20D94A1C-A4FE-48F2-9366-84130EDEF12EQ33246499-236B10D4-AADC-4FA6-9193-CF36AB3EF6DBQ33548383-478A51F1-16EC-46ED-927C-FAD5C4D12EFBQ33809764-569D12D7-EDBB-413F-80C0-65139923057BQ34687606-F50D44D3-751B-4DA2-B410-1767BE64F197Q35018746-A3FF0BE8-73F3-4DD2-997D-989F8AAB7758Q35691563-6A4389E8-8017-493A-875F-394672CE4253Q36187310-2555E11E-E980-48EA-BF10-A43DDA2B1D46Q36602569-AC81F5EF-F7FF-407E-8535-60528D65CC06Q36627600-6D804A7F-AD67-41B6-ABCB-A4D4BAED0D58Q36642995-E0FD45FC-94B2-4EF4-82A8-84DE6597F882Q36919195-B77C23EB-2E8B-48EE-B41F-74AE8E762CAEQ37016395-3D3C4CB0-5FA1-4174-91D6-9BA80E48FCBCQ37052897-A97CB147-756F-46A8-A52B-E61EE35C958AQ37120275-075C0E4A-7788-4D71-9942-ECAC0EE874CAQ37362637-0DD934BB-CEB0-4971-ACDB-B752B32A945DQ37705964-2379C02B-B7FB-473F-BEF6-55EC31733B5AQ38029897-7EF7F69D-E9A2-44EF-B67B-DC2239D2F18BQ38179828-BB931677-4104-42BE-ACD2-8CB34C116E7FQ38640470-91C24B02-C97E-4286-85F6-3557657275D2Q38836844-81C03FD5-FF91-40F4-AAF7-358D0D55A0B4Q39116600-5667CED3-73D3-4876-9133-429749EAE7E2Q40131511-9B4E0603-0869-444F-85EF-9D56715838AAQ40430437-B0197622-A4CA-411C-83CD-1B76707759A3Q40551207-CC71CE15-DAE0-45B0-8394-47206BD6C1D5Q46694340-781C46D5-655C-4347-8047-7D6C2604FE01Q47095192-B470815A-56BB-40CD-92AA-234262EECFABQ47177315-44F35470-A84F-4854-8E6B-BFDD6FC6C259Q49612029-ADEFD3FA-473E-421A-A059-ADBCA375F0F5Q50287337-B0FBA4A8-324A-4398-8656-D17CB38A1C4AQ57826033-40441242-3EF5-4C9D-B011-A36550C3C1E3
P2860
Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/07/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/01)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في يوليو 2003)
@ar
name
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@ast
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@en
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@nl
type
label
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@ast
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@en
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@nl
prefLabel
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@ast
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@en
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@nl
P2093
P2860
P3181
P1476
Loss of Bard1, the heterodimer ...... ty and chromosomal instability
@en
P2093
Ellen E. McCarthy
Julide T. Celebi
Richard Baer
Thomas Ludwig
P2860
P304
P3181
P356
10.1128/MCB.23.14.5056-5063.2003
P407
P577
2003-07-01T00:00:00Z