The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency
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Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cellsInhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domainElevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomasA protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolutionNeural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signalsExpression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational controlDistinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformationThe relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cellsHuman spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells.Neuregulin-increased expression of acetylcholine receptor epsilon-subunit gene requires ErbB interaction with Shc.Take your partners, please--signal diversification by the erbB family of receptor tyrosine kinases.Signal transduction in mammary tumorigenesis: a transgenic perspective.A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancerCell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationshipsCell cycle-dependent regulation of p185neu: a relationship between disruption of this regulation and transformation.Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase.Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.Clinical significance of erbB-2 (HER-2/neu) protein.NF-kappaB activation in melanoma.Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinaseEfficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activationeps15, a novel tyrosine kinase substrate, exhibits transforming activity.A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.Mitogenic signals and transforming potential of Nyk, a newly identified neural cell adhesion molecule-related receptor tyrosine kinase.Neu and its ligands: from an oncogene to neural factors.Functional analysis of Csk and CHK kinases in breast cancer cells.C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines.c-Cbl is a suppressor of the neu oncogene.Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2.HER-2/neu signal transduction in human breast and ovarian cancer.Detection of the ligand activity of the c-erbB-2 protein in calf serum.Specificity within the EGF family/ErbB receptor family signaling network.A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells.PLCG1 binds to p-ERBB2:p-EGFR
P2860
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P2860
The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency
description
1991 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1991
@ast
im April 1991 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1991/04/01)
@sk
vědecký článek publikovaný v roce 1991
@cs
wetenschappelijk artikel (gepubliceerd op 1991/04/01)
@nl
наукова стаття, опублікована у квітні 1991
@uk
مقالة علمية (نشرت في أبريل 1991)
@ar
name
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@ast
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@en
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@nl
type
label
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@ast
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@en
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@nl
prefLabel
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@ast
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@en
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@nl
P2093
P2860
P356
P1476
The erbB-2 mitogenic signaling ...... with erbB-2 mitogenic potency
@en
P2093
C. J. Molloy
F. Fazioli
O. Segatto
P. P. Di Fiore
S. G. Rhee
P2860
P304
P356
10.1128/MCB.11.4.2040
P407
P577
1991-04-01T00:00:00Z