Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function - Test2 - elhamkhani - TriplyDB

Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function

Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function

http://www.wikidata.org/entity/Q28767351

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Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini.Myocardin-Related Transcription Factor A Activation by Competition with WH2 Domain Proteins for Actin Binding.Control of mammary myoepithelial cell contractile function by α3β1 integrin signalling Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation Role for MKL1 in megakaryocytic maturation.MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation.Framework to function: mechanosensitive regulators of gene transcription An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.Synergistic activation of cardiac genes by myocardin and Tbx5.Linking actin dynamics and gene transcription to drive cellular motile functions.Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells Myoepithelial cell contraction and milk ejection are impaired in mammary glands of mice lacking smooth muscle alpha-actin Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts.MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A.Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy.Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1 Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics.Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction.Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes.The myocardin-related transcription factor, MASTR, cooperates with MyoD to activate skeletal muscle gene expression.Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis Regulation of myocardin factor protein stability by the LIM-only protein FHL2 Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1.Myocardin marks the earliest cardiac gene expression and plays an important role in heart development.Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.Novel insights into the disease etiology of laminopathies.Signaling mechanisms that regulate smooth muscle cell differentiation.The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation.Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis.Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation.Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling.Myocardin-related transcription factors are required for cardiac development and function.

P2860

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P2860

Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function

http://www.wikidata.org/entity/Q28767351

description

2006 nî lūn-bûn

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2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2006 թվականի օգոստոսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年论文

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Acute myeloid leukemia-associa ...... ator of mammary gland function

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Acute myeloid leukemia-associa ...... ator of mammary gland function

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Molecular and Cellular Biology

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Acute myeloid leukemia-associa ...... ator of mammary gland function

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Amina Fu

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Carl W Jackson

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Gertraud W Robinson

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Jing Ma

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Johann K Hitzler

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Jonathan M Shillingford

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Kelli Boyd

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Stephan W Morris

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Wu Xu

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Yi Sun

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P2860

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent

Bioconductor: open software development for computational biology and bioinformatics

Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

Gene ontology: tool for the unification of biology

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.

Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation

Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells

Potentiation of serum response factor activity by a family of myocardin-related transcription factors.

Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice

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5809-5826

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scholarly article

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10.1128/MCB.00024-06

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15

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26

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Lothar Hennighausen

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2006-08-01T00:00:00Z

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6939135

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16847333

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1592762

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