Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
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Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectinThe synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementiaDeficiency of disulfide bonds facilitating fibrillogenesis of endostatinCell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21qDirect visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brainMisfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulationPauling and Corey's alpha-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid diseaseThe toxicity of amyloid β oligomersAutoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometrySecondary structure and dynamics of micelle bound beta- and gamma-synucleinLipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in miceMisfolded proteins partition between two distinct quality control compartmentsAmyloids: friend or foe?Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregatesAlpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal proteinSequence determinants of protein aggregation: tools to increase protein solubility.Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2Insights into Mechanisms of Chronic NeurodegenerationElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsMechanisms of islet amyloidosis toxicity in type 2 diabetesYeast studies reveal moonlighting functions of the ancient actin cytoskeletonMisfolding and amyloid aggregation of apomyoglobinMechanisms for quality control of misfolded transmembrane proteinsTangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing ProblemAlzheimer's disease--a panorama glimpseThe relationship between amyloid structure and cytotoxicityAmyloid diseases of the heart: current and future therapiesFunction and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescenceWireless-electrodeless quartz-crystal-microbalance biosensors for studying interactions among biomolecules: a review.The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegenerationAn ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegansIndividual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells.Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease.Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activityA helical structural nucleus is the primary elongating unit of insulin amyloid fibrilsMapping the conformational dynamics and pathways of spontaneous steric zipper Peptide oligomerizationStabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formationCrystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent MannerEnhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS
P2860
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P2860
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Inherent toxicity of aggregate ...... or protein misfolding diseases
@ast
Inherent toxicity of aggregate ...... or protein misfolding diseases
@en
type
label
Inherent toxicity of aggregate ...... or protein misfolding diseases
@ast
Inherent toxicity of aggregate ...... or protein misfolding diseases
@en
prefLabel
Inherent toxicity of aggregate ...... or protein misfolding diseases
@ast
Inherent toxicity of aggregate ...... or protein misfolding diseases
@en
P2093
P50
P3181
P356
P1433
P1476
Inherent toxicity of aggregate ...... or protein misfolding diseases
@en
P2093
Christopher M Dobson
Fabiana Baroni
Fabrizio Chiti
Giampietro Ramponi
Lucia Formigli
P2888
P304
P3181
P356
10.1038/416507A
P407
P577
2002-04-01T00:00:00Z
P5875
P6179
1020109471