Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model - Test2 - elhamkhani - TriplyDB

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

http://www.wikidata.org/entity/Q29617937

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin Hsp90-Tau complex reveals molecular basis for specificity in chaperone action Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy HDAC2 negatively regulates memory formation and synaptic plasticity.Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.Reversing EphB2 depletion rescues cognitive functions in Alzheimer model Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease Synapses and Alzheimer's disease Untangling tau imaging Temperature and toxic Tau in Alzheimer's disease: new insights Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration The amyloid hypothesis of Alzheimer's disease at 25 years Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity Tau Oligomers: The Toxic Player at Synapses in Alzheimer's Disease Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia SUMOylation: Novel Neuroprotective Approach for Alzheimer's Disease?Diverse molecular targets for therapeutic strategies in Alzheimer's disease Alzheimer's therapeutics: translation of preclinical science to clinical drug development Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders The involvement of microRNAs in neurodegenerative diseases Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies Breaking the Code of Amyloid-β Oligomers The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets Connecting the dots between tau dysfunction and neurodegeneration Alternative neural circuitry that might be impaired in the development of Alzheimer disease Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem

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P2860

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

http://www.wikidata.org/entity/Q29617937

description

2007 nî lūn-bûn

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2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2007 թվականի մայիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Reducing endogenous tau amelio ...... lzheimer's disease mouse model

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Reducing endogenous tau amelio ...... lzheimer's disease mouse model

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Reducing endogenous tau amelio ...... lzheimer's disease mouse model

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Reducing endogenous tau amelio ...... lzheimer's disease mouse model

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Reducing endogenous tau amelio ...... lzheimer's disease mouse model

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Reducing endogenous tau amelio ...... lzheimer's disease mouse model

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SCIENCE.1141736

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Reducing endogenous tau amelio ...... lzheimer's disease mouse model

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Fengrong Yan

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Gui-Qiu Yu

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Hilary Gerstein

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Irene H Cheng

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Jorge J Palop

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Kimberly Scearce-Levie

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Lennart Mucke

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Tiffany Wu

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750-754

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scholarly article

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1791542

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10.1126/SCIENCE.1141736

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5825

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316

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Erik D. Roberson

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2007-05-01T00:00:00Z

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6351033

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17478722

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Alzheimer's disease