Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.
about
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatmentMolecular mechanisms of disease-causing missense mutationsCoarse-grained molecular simulation of epidermal growth factor receptor protein tyrosine kinase multi-site self-phosphorylationAxitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformationDynamically-driven inactivation of the catalytic machinery of the SARS 3C-like protease by the N214A mutation on the extra domainMutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanismsSimulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionTowards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational DynamicsProtein kinases: evolution of dynamic regulatory proteinsDifferential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.The energy landscape analysis of cancer mutations in protein kinasesSequence and structure signatures of cancer mutation hotspots in protein kinasesLarge conformational changes in proteins: signaling and other functions.Dynamically-driven enhancement of the catalytic machinery of the SARS 3C-like protease by the S284-T285-I286/A mutations on the extra domain.Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditionsProbing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinasesAllosteric communication across the native and mutated KIT receptor tyrosine kinase.Computational study of the "DFG-flip" conformational transition in c-Abl and c-Src tyrosine kinases.Rapid and accurate ranking of binding affinities of epidermal growth factor receptor sequences with selected lung cancer drugsEffect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM.Irreversible inhibitors of c-Src kinase that target a nonconserved cysteine.Structure and dynamic regulation of Abl kinases.Molecular modeling of ErbB4/HER4 kinase in the context of the HER4 signaling network helps rationalize the effects of clinically identified HER4 somatic mutations on the cell phenotype.Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors.Structure-functional prediction and analysis of cancer mutation effects in protein kinases.Small-world networks of residue interactions in the Abl kinase complexes with cancer drugs: topology of allosteric communication pathways can determine drug resistance effects.The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review).Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types.Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinasesStructural bioinformatics and protein docking analysis of the molecular chaperone-kinase interactions: towards allosteric inhibition of protein kinases by targeting the hsp90-cdc37 chaperone machinery.Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins.Molecular dynamics simulation reveals structural and thermodynamic features of kinase activation by cancer mutations within the epidermal growth factor receptor.Conformational regulation of the EGFR kinase core by the juxtamembrane and C-terminal tail: a molecular dynamics study.
P2860
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P2860
Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Hierarchical modeling of activ ...... ctivation by cancer mutations.
@ast
Hierarchical modeling of activ ...... ctivation by cancer mutations.
@en
type
label
Hierarchical modeling of activ ...... ctivation by cancer mutations.
@ast
Hierarchical modeling of activ ...... ctivation by cancer mutations.
@en
prefLabel
Hierarchical modeling of activ ...... ctivation by cancer mutations.
@ast
Hierarchical modeling of activ ...... ctivation by cancer mutations.
@en
P2860
P1476
Hierarchical modeling of activ ...... ctivation by cancer mutations.
@en
P2093
Anshuman Dixit
P2860
P304
P356
10.1371/JOURNAL.PCBI.1000487
P577
2009-08-28T00:00:00Z