Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit
about
The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assemblyPutting the structure into complementMembrane attack by complement: the assembly and biology of terminal complement complexesConformational changes during pore formation by the perforin-related protein pleurotolysinStructure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicronStructure of human C8 protein provides mechanistic insight into membrane pore formation by complement.Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.Killing of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer ProteinsPerforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytesThe Apicomplexan CDC/MACPF-like pore-forming proteins.Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins.Membrane assembly of the cholesterol-dependent cytolysin pore complex.The MACPF/CDC family of pore-forming toxins.Structural and functional analysis of perforin mutations in association with clinical data of familial hemophagocytic lymphohistiocytosis type 2 (FHL2) patients.Topology of the membrane-bound form of complement protein C9 probed by glycosylation mapping, anti-peptide antibody binding, and disulfide modification.Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within EuteleostomiEffects of MACPF/CDC proteins on lipid membranes.Structure of human complement C8, a precursor to membrane attack.Perforin deficiency and susceptibility to cancer.Perforin: structure, function, and role in human immunopathology.Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9Perforin activity at membranes leads to invaginations and vesicle formation.Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.Lessons from high-throughput protein crystallization screening: 10 years of practical experience.Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer.The battlefield of perforin/granzyme cell death pathways.Killing machines: three pore-forming proteins of the immune system.The structure and function of mammalian membrane-attack complex/perforin-like proteins.The mystery behind membrane insertion: a review of the complement membrane attack complexMembrane pore formation by human complement: functional importance of the transmembrane β-hairpin (TMH) segments of C8α and C9.The Membrane Attack Complex/Perforin Superfamily.Defense and death responses to pore forming toxins
P2860
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P2860
Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Crystal structure of the MACPF ...... plex with the C8 gamma subunit
@ast
Crystal structure of the MACPF ...... plex with the C8 gamma subunit
@en
type
label
Crystal structure of the MACPF ...... plex with the C8 gamma subunit
@ast
Crystal structure of the MACPF ...... plex with the C8 gamma subunit
@en
prefLabel
Crystal structure of the MACPF ...... plex with the C8 gamma subunit
@ast
Crystal structure of the MACPF ...... plex with the C8 gamma subunit
@en
P2860
P50
P1476
Crystal structure of the MACPF ...... plex with the C8 gamma subunit
@en
P2093
James M Sodetz
Leslie L Lovelace
P2860
P304
P356
10.1016/J.JMB.2008.03.061
P407
P577
2008-04-03T00:00:00Z