The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing - Test2 - elhamkhani - TriplyDB

The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing

The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing

http://www.wikidata.org/entity/Q30424920

about

Myotonic dystrophy: is a narrow focus obscuring the rest of the field?Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay Report on the 3rd Ottawa International Conference on Neuromuscular Biology, Disease and Therapy - September 24-26, 2015, Ottawa, Canada.Age of onset of RNA toxicity influences phenotypic severity: evidence from an inducible mouse model of myotonic dystrophy (DM1).RNA-protein interactions in unstable microsatellite diseases.RNA-binding protein misregulation in microsatellite expansion disorders Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model.Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5 Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65 Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain Staufen1s role as a splicing factor and a disease modifier in Myotonic Dystrophy Type I.Antisense oligonucleotides: rising stars in eliminating RNA toxicity in myotonic dystrophy.Staufen1 impairs stress granule formation in skeletal muscle cells from myotonic dystrophy type 1 patients.STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.Posttranscriptional regulation of insulin family ligands and receptors Genome-wide analysis of Staufen-associated mRNAs identifies secondary structures that confer target specificity Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases.Compound loss of muscleblind-like function in myotonic dystrophy.Treatment of type 1 myotonic dystrophy by engineering site-specific RNA endonucleases that target (CUG)(n) repeats.Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events.Developmental insights into the pathology of and therapeutic strategies for DM1: Back to the basics.Molecular mechanisms in DM1 - a focus on foci.Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog.Cell cycle-dependent regulation of the RNA-binding protein Staufen1.Can Human Pluripotent Stem Cell-Derived Cardiomyocytes Advance Understanding of Muscular Dystrophies?DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1.Staufen1 senses overall transcript secondary structure to regulate translation Chronic 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6/2 Mouse Model of Huntington's Disease.The RNA-binding protein Staufen1 impairs myogenic differentiation via a c-myc-dependent mechanism.Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.CLIPing Staufen to secondary RNA structures: size and location matter!Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin-NFAT signaling in skeletal muscle of DM1 mice.Cytoplasmic functions of long noncoding RNAs.Diversification of the muscle proteome through alternative splicing.Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy.Cells of Matter-In Vitro Models for Myotonic Dystrophy.The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity

P2860

Q26830455-52A3F741-07A9-4473-B6A0-F3EA149C56CF Q27677008-917B310D-1AEE-4C2E-8B21-0A419C5352AF Q30355125-56686E11-2BB0-428E-8498-61A4FEAABCEC Q30417185-BD60CE82-0E37-4C5D-A3A4-70B6CA03A5B4 Q34243144-1360CBEB-09A9-4FEF-9B47-36BB68C2527C Q35789502-C71C1093-E334-4D67-910B-42F9950CB62D Q35802850-6B07E004-1A8B-4ED4-B84A-6C14F2A865DB Q35818784-1E31E55C-020C-4D24-944F-04D06640CF74 Q35896064-55B4D060-C77B-4286-9B9F-F97398B5B17D Q35908266-7DB3501F-FC7B-4AF7-9DAE-07C99446C1EF Q35984230-5FEE3BB6-B46E-4E13-ABB2-A4B6614DF4CC Q36151477-03A0BC27-77D8-4EE4-B852-3120E8938A5E Q36848720-9CC21FE7-F29B-40C9-B71A-556A2EFC2C4A Q36944554-4374A2D7-2A39-427D-A4E3-5690A5283ACE Q37019220-7DF035E7-264E-4B07-8670-AEC9522800B0 Q37078868-738BCFE7-F7B7-4F24-90BB-9496781BAD48 Q37225291-F2C08A85-72D7-4B36-B918-526874A9E148 Q37271103-761EC13D-1D04-4019-9480-C7C0CF91C014 Q37401085-2A278EA1-7D5B-4E88-9A97-619D6FD9BA52 Q37557193-0A231C70-C5F1-40F8-B1EC-D94F70697C11 Q37562085-76C44B84-4FC5-49B9-8DD8-6BE2D0DC77F3 Q37648694-4BEE4C8C-00EE-4613-85B1-0F25DE59992A Q38287631-2676E1FC-6DCA-46D4-8B1C-E1935ADEF4BD Q38326275-7182B189-5335-4890-AA3E-6EAB4A409E2E Q38860146-758D6A79-DBD6-4226-8791-56ADEDF82579 Q38987396-A4D2533F-F5AB-4E8B-9FD7-114F9D5B92D0 Q39010745-83FD736C-5768-41B4-BD27-CB30307B609F Q41002587-0F2FEFCD-F7BD-42C4-AD09-27B8D4EEA9C1 Q41857394-B3D98F72-3ABE-46F0-A426-9384DA0D0C28 Q42228159-27034002-B8FC-45A0-A4C0-D2E518226D50 Q43004450-32FDC67B-58C0-41AB-9A96-630995348944 Q47332454-A39D7CCD-F448-4399-8472-91EA93D24588 Q47370019-5D98C3A0-84C7-4C49-8F1E-5E27F80EE62B Q50755664-7A0E1D44-5642-4EF9-91CA-30598CA7959C Q51764928-3028AB1A-831E-4DF6-878E-457C19729F0E Q52671372-75C9312D-227B-45C8-BA01-A5B8223D48D5 Q54982478-88512AAF-2C31-4B30-8AFB-3DB75FB7B9DE Q55100992-9424FFBC-0691-4C8D-8991-D77FB91AB0F9 Q59136650-87AF78BE-AE9E-4C4E-9CEB-69C9329C5FCB

P2860

The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing

http://www.wikidata.org/entity/Q30424920

description

2012 nî lūn-bûn

@nan

2012 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի մարտին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

The RNA-binding protein Staufe ...... alternative pre-mRNA splicing

@ast

The RNA-binding protein Staufe ...... alternative pre-mRNA splicing

@en

type

label

The RNA-binding protein Staufe ...... alternative pre-mRNA splicing

@ast

The RNA-binding protein Staufe ...... alternative pre-mRNA splicing

@en

prefLabel

The RNA-binding protein Staufe ...... alternative pre-mRNA splicing

@ast

The RNA-binding protein Staufe ...... alternative pre-mRNA splicing

@en

P1433

Q30424920-E5F770B9-AFB8-4A4E-A17C-AADDC679AEB7

P1476

Q30424920-F91B77BD-D3C4-4A6F-9122-BA9B2D0A914B

P2093

Q30424920-14A71C83-27A8-4B9F-9C38-43E36CA59DD1

Q30424920-482CAD6A-E865-4B07-A669-3EACB5DA7964

Q30424920-65841025-E1E0-47BE-8993-4938EB4B97D0

Q30424920-787E8EC5-8B7F-48F3-80C6-A275F45508C7

Q30424920-86DB392A-2C65-4C48-9BD3-B738C045ECA9

Q30424920-D12654BC-0512-4647-888A-0BA212B4CCAA

Q30424920-E7FD2D20-130F-43E3-92B5-9B037A9A251E

P2860

Q30424920-0A84D081-6753-48EB-B771-859E0C16F68C

Q30424920-0C15A758-8C31-4E42-B6FD-34EC8AF83DF1

Q30424920-1379A906-0798-4343-AEB9-5BDB555C8B50

Q30424920-17704F87-A9D3-444D-BF81-E319F72AB0DA

Q30424920-1812A41E-E304-4B25-9B35-C7A2EFFDFB60

Q30424920-1ADA768C-3ED3-48A1-8ABF-BAA0880CEE3F

Q30424920-1B6B0648-9F66-4B99-A8BB-A0508D26498D

Q30424920-2643DC87-88AB-4CFC-9AF0-2F7512BBDF65

Q30424920-2A5EB3D0-1334-4D52-8C57-381A6201DB29

Q30424920-30A0C45D-71F0-4A67-AF90-77E4EBCE81DA

P304

Q30424920-3EEBE517-1199-46CE-9415-733CED2A4D29

P31

Q30424920-C7A4E562-0888-4D0E-91D2-B9B38A4916F7

P356

Q30424920-AE03F7B4-98A0-4181-A550-DF0510F953E2

P407

Q30424920-0E1F26A0-F94C-4BF9-9E58-F4FB1B6BA76A

P433

Q30424920-C9DA6C8F-3319-44CD-B3E6-7E671653973B

P478

Q30424920-2091FE16-3A55-46BE-8B02-4E6F5E9C349F

P577

Q30424920-6569FD06-24E2-42D9-B41F-A815EAE67870

P5875

Q30424920-80994777-7CCA-4596-9B87-EFEE89D71349

P698

Q30424920-F806AC5B-16DB-4FA3-9F2C-16735F463D36

P932

Q30424920-2EDCE876-F2A9-4D10-8FFA-6E2034ACE8B8

P356

P1433

Journal of Cell Biology

P1476

The RNA-binding protein Staufe ...... alternative pre-mRNA splicing

@en

P2093

Aymeric Ravel-Chapuis

http://www.w3.org/2001/XMLSchema#string

Bernard J Jasmin

http://www.w3.org/2001/XMLSchema#string

Guy Bélanger

http://www.w3.org/2001/XMLSchema#string

Jocelyn Côté

http://www.w3.org/2001/XMLSchema#string

Luc DesGroseillers

http://www.w3.org/2001/XMLSchema#string

Mani S Mahadevan

http://www.w3.org/2001/XMLSchema#string

Ramesh S Yadava

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay

Muscleblind proteins regulate alternative splicing

Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing

Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells

Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy

Molecular mapping of the determinants involved in human Staufen-ribosome association

Molecular basis for impaired muscle differentiation in myotonic dystrophy

Identification of two RNA-binding proteins associated with human telomerase RNA

P304

699-712

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1083/JCB.201108113

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

196

http://www.w3.org/2001/XMLSchema#string

P577

2012-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221724335

http://www.w3.org/2001/XMLSchema#string

P698

22431750

http://www.w3.org/2001/XMLSchema#string

P932

3308689

http://www.w3.org/2001/XMLSchema#string