MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
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The neurogenetics of alternative splicingDefective control of pre-messenger RNA splicing in human diseaseReport on the 3rd Ottawa International Conference on Neuromuscular Biology, Disease and Therapy - September 24-26, 2015, Ottawa, Canada.Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes.Myotonic Dystrophies: State of the Art of New Therapeutic Developments for the CNS.RNA metabolism in neurodegenerative disease.A flow cytometry-based screen identifies MBNL1 modulators that rescue splicing defects in myotonic dystrophy type I.Distal Alternative Last Exons Localize mRNAs to Neural ProjectionsSplicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila.Dysregulation of mRNA Localization and Translation in Genetic DiseaseTrinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal DystrophyParadoxical overexpression of MBNL2 in hepatocellular carcinoma inhibits tumor growth and invasion.Roles for RNA-binding proteins in development and disease.Dynamic landscape of alternative polyadenylation during retinal development.Alternative splicing as a regulator of development and tissue identity.Optical Mapping Approaches on Muscleblind-Like Compound Knockout Mice for Understanding Mechanistic Insights Into Ventricular Arrhythmias in Myotonic Dystrophy.TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases.RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2.Reduced cytoplasmic MBNL1 is an early event in a brain-specific mouse model of myotonic dystrophy.Repeat-associated non-AUG (RAN) translation and other molecular mechanisms in Fragile X Tremor Ataxia Syndrome.Increased EEG Theta Spectral Power in Sleep in Myotonic Dystrophy Type 1.Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy.rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences.Core Clinical Phenotypes in Myotonic Dystrophies.Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism.Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1.miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.Control of CNS functions by RNA-binding proteins in neurological diseases
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P2860
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
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2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
@zh-hk
2015年論文
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2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
@ast
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
@en
type
label
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
@ast
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
@en
prefLabel
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
@ast
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
@en
P2093
P2860
P50
P1433
P1476
MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain
@en
P2093
Apoorva Mohan
Chaolin Zhang
H Brent Clark
John W Day
Joline Dalton
Kenji Takamura
Konstantinos Charizanis
Kuang-Yung Lee
Laura P W Ranum
Marianne Goodwin
P2860
P304
P356
10.1016/J.CELREP.2015.07.029
P577
2015-08-06T00:00:00Z