Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells - Test2 - elhamkhani - TriplyDB

Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells

Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells

http://www.wikidata.org/entity/Q30438819

about

Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle Insights into granulosa cell tumors using spontaneous or genetically engineered mouse models Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human.Loss of GATA-6 and GATA-4 in granulosa cells blocks folliculogenesis, ovulation, and follicle stimulating hormone receptor expression leading to female infertility.Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization.Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells Manipulating insulin signaling to enhance mosquito reproduction.Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice.Phosphoinositide 3-kinase p110δ mediates estrogen- and FSH-stimulated ovarian follicle growth Selective Smad4 knockout in ovarian preovulatory follicles results in multiple defects in ovulation Minireview: physiological and pathological actions of RAS in the ovary.TOP2β is essential for ovarian follicles that are hypersensitive to chemotherapeutic drugs Prostaglandin F2alpha represses IGF-I-stimulated IRS1/phosphatidylinositol-3-kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase.The ovary: basic biology and clinical implications Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary.Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles.Activation of dormant ovarian follicles to generate mature eggs Preventing granulosa cell apoptosis through the action of a single microRNA The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation.Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment Intraovarian control of early folliculogenesis Role of Dicer in female fertility.Promotion of ovarian follicle growth following mTOR activation: synergistic effects of AKT stimulators Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice.Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis.Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain.Minireview: animal models and mechanisms of ovarian cancer development.

P2860

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P2860

Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells

http://www.wikidata.org/entity/Q30438819

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2008 nî lūn-bûn

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2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2008 թվականի հուլիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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Molecular Endocrinology

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P2093

Heng-Yu Fan

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JoAnne S Richards

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Nicola Cahill

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Zhilin Liu

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice

Generalized lacZ expression with the ROSA26 Cre reporter strain

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

The biology and clinical relevance of the PTEN tumor suppressor pathway

Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1

Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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2128-2140

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10.1210/ME.2008-0095

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9

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22

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2008-07-07T00:00:00Z

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2631369

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