Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
about
Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayA water-mediated and substrate-assisted catalytic mechanism for Sulfolobus solfataricus DNA polymerase IV.Polymerase-tailored variations in the water-mediated and substrate-assisted mechanism for nucleotidyl transfer: insights from a study of T7 DNA polymerase.Computational delineation of tyrosyl-substrate recognition and catalytic landscapes by the epidermal growth factor receptor tyrosine kinase domain.Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selectionGlobal conformational dynamics of a Y-family DNA polymerase during catalysis.A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantRNA polymerase II with open and closed trigger loops: active site dynamics and nucleic acid translocationEffect of oxidatively damaged DNA on the active site preorganization during nucleotide incorporation in a high fidelity polymerase from Bacillus stearothermophilus."Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Prechemistry versus preorganization in DNA replication fidelity.Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase betaCoupling of fast and slow modes in the reaction pathway of the minimal hammerhead ribozyme cleavage.Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase.Perspective: pre-chemistry conformational changes in DNA polymerase mechanismsInsertion of oxidized nucleotide triggers rapid DNA polymerase openingCatalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies.Progress in ab initio QM/MM free-energy simulations of electrostatic energies in proteins: accelerated QM/MM studies of pKa, redox reactions and solvation free energiesComputational simulation strategies for analysis of multisubunit RNA polymerases.Relationship between conformational changes in pol lambda's active site upon binding incorrect nucleotides and mismatch incorporation rates.Biomolecularmodeling and simulation: a field coming of age.Why nature really chose phosphate.Applications of quantum mechanical/molecular mechanical methods to the chemical insertion step of DNA and RNA polymerization.Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.Computational delineation of the catalytic step of a high-fidelity DNA polymerase.Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase βAddressing open questions about phosphate hydrolysis pathways by careful free energy mapping.Substrate recognition by norovirus polymerase: microsecond molecular dynamics study.Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.Identification of the nucleophilic factors and the productive complex for the editing reaction by leucyl-tRNA synthetase.Computational Simulations of DNA Polymerases: Detailed Insights on Structure/Function/Mechanism from Native Proteins to Cancer Variants.Correlation between electron localization and metal ion mutagenicity in DNA synthesis from QM/MM calculations.Stepwise walden inversion in nucleophilic substitution at phosphorusPrechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limiting
P2860
Q27679382-F7A82F88-9478-465D-B54E-70DFF63CA8B0Q30483153-9FE90158-0309-4E48-93C8-E19B15D64077Q30492631-D9380685-E91F-4E8F-97A8-87D7D7BC255AQ30581942-53CE1FD7-DA10-49CD-82C3-F9E1FF5B8EADQ31086167-024CFC74-00B8-46CA-8EB7-C438C3685234Q33512900-8AC983A7-2F47-4831-849A-D3088625C3D1Q33923598-F0C8E75D-C3BF-446A-9B6E-145AC712B907Q34206064-90A62C9F-CD4C-4A13-AB63-E1963DCECEF5Q34501365-7C7014C1-9DB6-4FA9-A653-C26903020953Q34743729-F7D05EF4-877A-47A8-BEB6-04A4EA07CEB6Q35212044-ADAC0167-7E8E-4652-A6B1-4D5B54C23EC8Q35751470-9C356FBA-7A67-4EEB-922F-8EF8E32B8E79Q35972956-74ECD1A8-2F32-491A-A720-147F7409B9DDQ36593746-A595EE40-D537-475B-8A66-79ABD9E1D3F1Q36642645-C27F2D57-3E43-4DA4-9A2F-F5560780BE65Q36914612-4D287682-31E2-4B00-BCD7-3F4D20179F4FQ36982357-13404363-65A6-42A8-9957-49438DF3B6BBQ37185158-80A0613A-FD41-42C2-9F9A-DEFD6C468FC2Q37313036-CD40FA59-162E-4592-B689-2ECE7C3A6536Q37362528-B41E499A-09ED-498F-A050-F53479D0EBFCQ37827906-E8C0CA3D-67BD-421A-A17D-93F3A6D31047Q38073986-B7134E77-F719-4FE9-B94C-323A9D569A63Q38280096-FB26940F-C4C4-4238-885C-83DD71710063Q38731525-65AC525B-7395-425D-BE54-1422C68BA43FQ40454946-27BB85A6-5839-4407-8AFE-9178A41D5B39Q42598180-D49F01C2-A40C-4BE2-8506-710343787FC7Q42682544-A8CE3142-0433-4212-B3E4-27B01F3A49C3Q45903781-951A5712-D8B7-4B66-8862-DCEA22CE5C6FQ46195063-ACC933AF-A2DF-441E-9AD2-A87BC5610B9DQ47741805-FEB7D11C-B8F9-4676-ACBD-4DE3B3C38793Q47848185-2442882C-DA93-470A-B094-EDB1020359D8Q54590413-CFF27540-D85F-450E-BBD6-76B0D7FF04FDQ56880688-4027DD86-E762-4D6F-804A-9315132BA480Q58072640-25487BAD-FD08-4EB7-8FBC-68D17D742979
P2860
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
@ast
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
@en
type
label
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
@ast
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
@en
prefLabel
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
@ast
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
@en
P2860
P1476
Correct and incorrect nucleotide incorporation pathways in DNA polymerase beta
@en
P2093
Ravi Radhakrishnan
Tamar Schlick
P2860
P304
P356
10.1016/J.BBRC.2006.09.059
P407
P577
2006-09-25T00:00:00Z