Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.
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Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cellsSignal-peptide-mediated translocation is regulated by a p97-AIRAPL complexUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesProtein disulfide isomerases in neurodegeneration: from disease mechanisms to biomedical applicationsExpression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunctionSGTA antagonizes BAG6-mediated protein triageCytoplasmic prion protein induces forebrain neurotoxicityFunctional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegenerationEndoplasmic reticulum stress, PrP trafficking, and neurodegeneration.Selective processing and metabolism of disease-causing mutant prion proteins.Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patientsSignal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.Cell type-specific neuroprotective activity of untranslocated prion protein.Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion proteinFunctional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.The intricate mechanisms of neurodegeneration in prion diseases.Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP.Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteinsPrion protein biosynthesis and its emerging role in neurodegeneration.Protein targeting and degradation are coupled for elimination of mislocalized proteins.Prion protein at the crossroads of physiology and disease.Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex.Prion neurotoxicity: insights from prion protein mutantsEndoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer.Evolutionary well-conserved region in the signal peptide of parathyroid hormone-related protein is critical for its dual localization through the regulation of ER translocation.Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integrationLow expression level of OB-Rb results from constitutive translocational attenuation attributable to a less efficient signal sequence.Prion degradation pathways: Potential for therapeutic intervention.Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.Mechanisms of prion-induced neurodegeneration.The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.Homodimerization as a molecular switch between low and high efficiency PrP C cell surface delivery and neuroprotective activity.
P2860
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P2860
Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Reduced translocation of nasce ...... tributes to neurodegeneration.
@ast
Reduced translocation of nasce ...... tributes to neurodegeneration.
@en
type
label
Reduced translocation of nasce ...... tributes to neurodegeneration.
@ast
Reduced translocation of nasce ...... tributes to neurodegeneration.
@en
prefLabel
Reduced translocation of nasce ...... tributes to neurodegeneration.
@ast
Reduced translocation of nasce ...... tributes to neurodegeneration.
@en
P2093
P2860
P1433
P1476
Reduced translocation of nasce ...... tributes to neurodegeneration.
@en
P2093
Lionel Feigenbaum
Neena S Rane
Oishee Chakrabarti
Sang-Wook Kang
P2860
P304
P356
10.1016/J.DEVCEL.2008.06.015
P407
P577
2008-09-01T00:00:00Z