ERAD: the long road to destruction - Test2 - elhamkhani - TriplyDB

ERAD: the long road to destruction

ERAD: the long road to destruction

http://www.wikidata.org/entity/Q28264823

about

A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps Mechanisms of the noxious inflammatory cycle in cystic fibrosis Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase Molecular composition of IMP1 ribonucleoprotein granules Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4 The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum Mpl traffics to the cell surface through conventional and unconventional routes Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3 SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation Calreticulin and Hsp90 stabilize the human insulin receptor and promote its mobility in the endoplasmic reticulum OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis Maspin (SERPINB5) is an obligate intracellular serpin Diversity of degradation signals in the ubiquitin-proteasome system Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling Inhibition of p97-dependent protein degradation by Eeyarestatin I The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3 EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites

P2860

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P2860

ERAD: the long road to destruction

http://www.wikidata.org/entity/Q28264823

description

2005 nî lūn-bûn

@nan

2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

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2005年論文

@zh-tw

2005年论文

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name

ERAD: the long road to destruction

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ERAD: the long road to destruction

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ERAD: the long road to destruction

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type

label

ERAD: the long road to destruction

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ERAD: the long road to destruction

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ERAD: the long road to destruction

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prefLabel

ERAD: the long road to destruction

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ERAD: the long road to destruction

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ERAD: the long road to destruction

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Nature Cell Biology

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ERAD: the long road to destruction

@en

P2093

Birgit Meusser

http://www.w3.org/2001/XMLSchema#string

Christian Hirsch

http://www.w3.org/2001/XMLSchema#string

Thomas Sommer

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P2860

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle

A membrane protein required for dislocation of misfolded proteins from the ER

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.

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1876210

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10.1038/NCB0805-766

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8

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1016418299

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16056268

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