Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. - Test2 - elhamkhani - TriplyDB

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.

http://www.wikidata.org/entity/Q30493907

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Novel therapeutic targets for pancreatic cancer Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Hedgehog Signaling in Pancreatic Fibrosis and Cancer The wound healing, chronic fibrosis, and cancer progression triad Cancer-associated fibroblasts in digestive tumors Personalized medicine in sporadic pancreatic cancer without homologous recombination-deficiency: are we any closer?A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins.Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma.A bioengineered heterotypic stroma-cancer microenvironment model to study pancreatic ductal adenocarcinoma.Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Disrupting the balance between tumor epithelia and stroma is a possible therapeutic approach for pancreatic cancer.The molecular targets for the diagnosis and treatment of pancreatic cancer.Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers.Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas Analysis of intercellular signal transduction in the tumor microenvironment.Aberrant signaling pathways in pancreatic cancer: a two compartment view.Contribution of microRNAs in understanding the pancreatic tumor microenvironment involving cancer associated stellate and fibroblast cells.Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.Pancreatic ductal adenocarcinoma: a review of immunologic aspects.Cancer associated fibroblasts have phenotypic and functional characteristics similar to the fibrocytes that represent a novel MDSC subset Molecular targeted approaches for treatment of pancreatic cancer.Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2'-deoxycytidine.Reliable Detection of Somatic Mutations in Fine Needle Aspirates of Pancreatic Cancer With Next-generation Sequencing: Implications for Surgical Management Tumor-Priming Smoothened Inhibitor Enhances Deposition and Efficacy of Cytotoxic Nanoparticles in a Pancreatic Cancer Model Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.Overexpression of ankyrin1 promotes pancreatic cancer cell growth.Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies.Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis.Sonic hedgehog signaling drives proliferation of synoviocytes in rheumatoid arthritis: a possible novel therapeutic target.Sonic hedgehog expression in a rat model of chronic pancreatitis.Hedgehog signaling and therapeutics in pancreatic cancer.Pancreatic cancer stem cell biology and its therapeutic implications.

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P2860

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.

http://www.wikidata.org/entity/Q30493907

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Overexpression of smoothened a ...... cancer-associated fibroblasts.

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Overexpression of smoothened a ...... cancer-associated fibroblasts.

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Overexpression of smoothened a ...... cancer-associated fibroblasts.

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Overexpression of smoothened a ...... cancer-associated fibroblasts.

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Overexpression of smoothened a ...... cancer-associated fibroblasts.

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Overexpression of smoothened a ...... cancer-associated fibroblasts.

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Clinical Cancer Research

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Kimberly Walter

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P2860

Activating Smoothened mutations in sporadic basal-cell carcinoma

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: identification of multiple polyadenylation sites and a stromal pattern of expression

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Patched acts catalytically to suppress the activity of Smoothened

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

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20215540

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