Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
about
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1The sonic hedgehog-patched-gli pathway in human development and diseaseHuman GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell CarcinomaRegulatory role for Krüppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis.A role of PDGFRalpha in basal cell carcinoma proliferationHedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumorsIndian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationCD200-expressing human basal cell carcinoma cells initiate tumor growthGLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cellsInduction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1The therapeutic potential of modulators of the Hedgehog-Gli signaling pathwayAberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and ChemoresistanceAn oncologist׳s friend: How Xenopus contributes to cancer researchContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapySonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activityCooperative E-box regulation of human GLI1 by TWIST and USFLocalization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreasHedgehog signaling and the Gli code in stem cells, cancer, and metastasesNuclear beta-catenin in basal cell carcinoma correlates with increased proliferationParadoxical dysregulation of the neural stem cell pathway sonic hedgehog-Gli1 in autoimmune encephalomyelitis and multiple sclerosisTrps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosisCharacterization of Glis2, a novel gene encoding a Gli-related, Krüppel-like transcription factor with transactivation and repressor functions. Roles in kidney development and neurogenesisKRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functionsMechanisms that underlie co-variation of the brain and faceSnail induction is an early response to Gli1 that determines the efficiency of epithelial transformationActivation of Erk by sonic hedgehog independent of canonical hedgehog signalling.Network modeling of TGFβ signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and Wnt pathway activationLMP4 regulates Tbx5 protein subcellular localization and activity.Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivoPost-transcriptional regulation of the gli1 oncogene by the expression of alternative 5' untranslated regions.Overexpression of a novel Xenopus rel mRNA gene induces tumors in early embryos.The NH2-terminal region of the active domain of sonic hedgehog is necessary for its signal transduction.PTCH1 +/- dermal fibroblasts isolated from healthy skin of Gorlin syndrome patients exhibit features of carcinoma associated fibroblasts.Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival.Developmental pathways: Sonic hedgehog-Patched-GLIThe sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors.
P2860
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P2860
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Activation of the transcriptio ...... alling pathway in skin tumours
@ast
Activation of the transcriptio ...... alling pathway in skin tumours
@en
Activation of the transcriptio ...... alling pathway in skin tumours
@nl
type
label
Activation of the transcriptio ...... alling pathway in skin tumours
@ast
Activation of the transcriptio ...... alling pathway in skin tumours
@en
Activation of the transcriptio ...... alling pathway in skin tumours
@nl
prefLabel
Activation of the transcriptio ...... alling pathway in skin tumours
@ast
Activation of the transcriptio ...... alling pathway in skin tumours
@en
Activation of the transcriptio ...... alling pathway in skin tumours
@nl
P2093
P3181
P356
P1433
P1476
Activation of the transcriptio ...... alling pathway in skin tumours
@en
P2093
P2888
P304
P3181
P356
10.1038/39918
P407
P577
1997-10-23T00:00:00Z
P5875
P6179
1030730422